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Ribosomal protein S21
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RPS21 ; HLDF; S21
External IDs OMIM180477 MGI1913731 HomoloGene90915 GeneCards: RPS21 Gene
RNA expression pattern
PBB GE RPS21 200834 s at tn.png
PBB GE RPS21 214097 at tn.png
More reference expression data
Species Human Mouse
Entrez 6227 66481
Ensembl ENSG00000171858 ENSMUSG00000039001
UniProt P63220 Q9CQR2
RefSeq (mRNA) NM_001024 NM_025587
RefSeq (protein) NP_001015 NP_079863
Location (UCSC) Chr 20:
60.96 – 60.96 Mb
Chr 2:
180.26 – 180.26 Mb
PubMed search [1] [2]

40S ribosomal protein S21 is a protein, encoded in humans by the RPS21 gene.[1][2][3]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S21E family of ribosomal proteins.

It is located in the cytoplasm. Alternative splice variants that encode different protein isoforms have been described, but their existence has not been verified. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3]


RPS21 has been shown to interact with Ribosomal protein SA.[4][5]


  1. ^ Bhat KS, Morrison SG (Aug 1993). "Primary structure of human ribosomal protein S21". Nucleic Acids Res 21 (12): 2939. doi:10.1093/nar/21.12.2939. PMC 309688. PMID 8332502. 
  2. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194. 
  3. ^ a b "Entrez Gene: RPS21 ribosomal protein S21". 
  4. ^ Stelzl, Ulrich; Worm Uwe, Lalowski Maciej, Haenig Christian, Brembeck Felix H, Goehler Heike, Stroedicke Martin, Zenkner Martina, Schoenherr Anke, Koeppen Susanne, Timm Jan, Mintzlaff Sascha, Abraham Claudia, Bock Nicole, Kietzmann Silvia, Goedde Astrid, Toksöz Engin, Droege Anja, Krobitsch Sylvia, Korn Bernhard, Birchmeier Walter, Lehrach Hans, Wanker Erich E (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell (United States) 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. ISSN 0092-8674. PMID 16169070. 
  5. ^ Sato, M; Saeki Y; Tanaka K; Kaneda Y (Mar 1999). "Ribosome-associated protein LBP/p40 binds to S21 protein of 40S ribosome: analysis using a yeast two-hybrid system". Biochem. Biophys. Res. Commun. (UNITED STATES) 256 (2): 385–90. doi:10.1006/bbrc.1999.0343. ISSN 0006-291X. PMID 10079194. 

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