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Ribosomal protein S27
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RPS27 ; MPS-1; MPS1; S27
External IDs OMIM603702 MGI1888676 HomoloGene803 GeneCards: RPS27 Gene
RNA expression pattern
PBB GE RPS27 200741 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6232 57294
Ensembl ENSG00000177954 ENSMUSG00000050621
UniProt P42677 Q6ZWU9
RefSeq (mRNA) NM_001030 NM_027015
RefSeq (protein) NP_001021 NP_081291
Location (UCSC) Chr 1:
153.96 – 153.96 Mb
Chr 3:
90.21 – 90.21 Mb
PubMed search [1] [2]

40S ribosomal protein S27 is a protein that in humans is encoded by the RPS27 gene.[1][2][3]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S27E family of ribosomal proteins. It contains a C4-type zinc finger domain that can bind to zinc. The encoded protein has been shown to be able to bind to nucleic acid. It is located in the cytoplasm as a ribosomal component, but it has also been detected in the nucleus. Studies in rat indicate that ribosomal protein S27 is located near ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3]


  1. ^ Tsui SK, Lee SM, Fung KP, Waye MM, Lee CY (Mar 1997). "Primary structures and sequence analysis of human ribosomal proteins L39 and S27". Biochem Mol Biol Int 40 (3): 611–6. doi:10.1080/15216549600201203. PMID 8908372. 
  2. ^ Fernandez-Pol JA, Klos DJ, Hamilton PD (Nov 1993). "A growth factor-inducible gene encodes a novel nuclear protein with zinc finger structure". J Biol Chem 268 (28): 21198–204. PMID 8407955. 
  3. ^ a b "Entrez Gene: RPS27 ribosomal protein S27 (metallopanstimulin 1)". 

Further reading[edit]