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Ribosomal protein S6 kinase, 90kDa, polypeptide 5
Protein RPS6KA5 PDB 1vzo.png
PDB rendering based on 1vzo.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RPS6KA5 ; MSK1; MSPK1; RLPK
External IDs OMIM603607 MGI1920336 HomoloGene48302 ChEMBL: 4237 GeneCards: RPS6KA5 Gene
EC number
RNA expression pattern
PBB GE RPS6KA5 204635 at tn.png
PBB GE RPS6KA5 204633 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9252 73086
Ensembl ENSG00000100784 ENSMUSG00000021180
UniProt O75582 Q8C050
RefSeq (mRNA) NM_004755 NM_153587
RefSeq (protein) NP_004746 NP_705815
Location (UCSC) Chr 14:
91.34 – 91.53 Mb
Chr 12:
100.55 – 100.73 Mb
PubMed search [1] [2]

Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene.[1][2][3]


RPS6KA5 has been shown to interact with CREB1.[1][4]


  1. ^ a b Deak M, Clifton AD, Lucocq LM, Alessi DR (September 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510. 
  2. ^ Jiang C, Yu L, Tu Q, Zhao Y, Zhang H, Zhao S (April 2000). "Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31→q32.1 by radiation hybrid mapping". Cytogenet Cell Genet 87 (3–4): 261–2. doi:10.1159/000015441. PMID 10702687. 
  3. ^ "Entrez Gene: RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5". 
  4. ^ Wang, X; Li W; Williams M; Terada N; Alessi D R; Proud C G (August 2001). "Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase". EMBO J. (England) 20 (16): 4370–9. doi:10.1093/emboj/20.16.4370. ISSN 0261-4189. PMC 125559. PMID 11500364. 

Further reading[edit]