RPS8

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Ribosomal protein S8
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RPS8 ; S8
External IDs OMIM600357 MGI98166 HomoloGene133061 GeneCards: RPS8 Gene
Orthologs
Species Human Mouse
Entrez 6202 20116
Ensembl ENSG00000142937 ENSMUSG00000047675
UniProt P62241 P62242
RefSeq (mRNA) NM_001012 NM_009098
RefSeq (protein) NP_001003 NP_033124
Location (UCSC) Chr 1:
45.24 – 45.24 Mb
Chr 4:
117.15 – 117.16 Mb
PubMed search [1] [2]

40S ribosomal protein S8 is a protein that in humans is encoded by the RPS8 gene.[1][2]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal tumors and colon polyps compared to matched normal colonic mucosa has been observed. This gene is co-transcribed with the small nucleolar RNA genes U38A, U38B, U39, and U40, which are located in its fourth, fifth, first, and second introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[2]

References[edit]

  1. ^ Davies B, Fried M (Mar 1993). "The structure of the human intron-containing S8 ribosomal protein gene and determination of its chromosomal location at 1p32-p34.1". Genomics 15 (1): 68–75. doi:10.1006/geno.1993.1011. PMID 8432552. 
  2. ^ a b "Entrez Gene: RPS8 ribosomal protein S8". 

Further reading[edit]