RRAS

From Wikipedia, the free encyclopedia
Jump to: navigation, search
This article is about the human protein. For the Microsoft API and server software, see Routing and Remote Access Service.
Related RAS viral (r-ras) oncogene homolog
Protein RRAS PDB 2fn4.png
PDB rendering based on 2fn4.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol RRAS
External IDs OMIM165090 MGI98179 HomoloGene4565 GeneCards: RRAS Gene
RNA expression pattern
PBB GE RRAS 212647 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6237 20130
Ensembl ENSG00000126458 ENSMUSG00000038387
UniProt P10301 P10833
RefSeq (mRNA) NM_006270 NM_009101
RefSeq (protein) NP_006261 NP_033127
Location (UCSC) Chr 19:
50.14 – 50.14 Mb
Chr 7:
45.02 – 45.02 Mb
PubMed search [1] [2]

Ras-related protein R-Ras is a protein that in humans is encoded by the RRAS gene.[1][2]


Interactions[edit]

RRAS has been shown to interact with RASSF5,[3] NCK1,[4] Bcl-2,[5] ARAF[6][7] and RALGDS.[8]

References[edit]

  1. ^ Lowe DG, Capon DJ, Delwart E, Sakaguchi AY, Naylor SL, Goeddel DV (February 1987). "Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes". Cell 48 (1): 137–46. doi:10.1016/0092-8674(87)90364-3. PMID 3098437. 
  2. ^ "Entrez Gene: RRAS related RAS viral (r-ras) oncogene homolog". 
  3. ^ Ortiz-Vega, Sara; Khokhlatchev Andrei; Nedwidek Maria; Zhang Xian-feng; Dammann Reinhard; Pfeifer Gerd P; Avruch Joseph (February 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene (England) 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. ISSN 0950-9232. PMID 11857081. 
  4. ^ Wang, B; Zou J X; Ek-Rylander B; Ruoslahti E (February 2000). "R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras". J. Biol. Chem. (UNITED STATES) 275 (7): 5222–7. doi:10.1074/jbc.275.7.5222. ISSN 0021-9258. PMID 10671570. 
  5. ^ Fernandez-Sarabia, M J; Bischoff J R (November 1993). "Bcl-2 associates with the ras-related protein R-ras p23". Nature (ENGLAND) 366 (6452): 274–5. doi:10.1038/366274a0. ISSN 0028-0836. PMID 8232588. 
  6. ^ Yuryev, Anton; Wennogle Lawrence P (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics (United States) 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. ISSN 0888-7543. PMID 12620389. 
  7. ^ Yuryev, A; Ono M; Goff S A; Macaluso F; Wennogle L P (July 2000). "Isoform-specific localization of A-RAF in mitochondria". Mol. Cell. Biol. (UNITED STATES) 20 (13): 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. ISSN 0270-7306. PMC 85938. PMID 10848612. 
  8. ^ Spaargaren, M; Bischoff J R (December 1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (26): 12609–13. doi:10.1073/pnas.91.26.12609. ISSN 0027-8424. PMC 45488. PMID 7809086. 

Further reading[edit]