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This article is about the human protein. For the Microsoft API and server software, see Routing and Remote Access Service.
Related RAS viral (r-ras) oncogene homolog
Protein RRAS PDB 2fn4.png
PDB rendering based on 2fn4.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol RRAS
External IDs OMIM165090 MGI98179 HomoloGene4565 GeneCards: RRAS Gene
RNA expression pattern
PBB GE RRAS 212647 at tn.png
More reference expression data
Species Human Mouse
Entrez 6237 20130
Ensembl ENSG00000126458 ENSMUSG00000038387
UniProt P10301 P10833
RefSeq (mRNA) NM_006270 NM_009101
RefSeq (protein) NP_006261 NP_033127
Location (UCSC) Chr 19:
50.14 – 50.14 Mb
Chr 7:
45.02 – 45.02 Mb
PubMed search [1] [2]

Ras-related protein R-Ras is a protein that in humans is encoded by the RRAS gene.[1][2]


RRAS has been shown to interact with RASSF5,[3] NCK1,[4] Bcl-2,[5] ARAF[6][7] and RALGDS.[8]


  1. ^ Lowe DG, Capon DJ, Delwart E, Sakaguchi AY, Naylor SL, Goeddel DV (February 1987). "Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes". Cell 48 (1): 137–46. doi:10.1016/0092-8674(87)90364-3. PMID 3098437. 
  2. ^ "Entrez Gene: RRAS related RAS viral (r-ras) oncogene homolog". 
  3. ^ Ortiz-Vega, Sara; Khokhlatchev Andrei; Nedwidek Maria; Zhang Xian-feng; Dammann Reinhard; Pfeifer Gerd P; Avruch Joseph (February 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene (England) 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. ISSN 0950-9232. PMID 11857081. 
  4. ^ Wang, B; Zou J X; Ek-Rylander B; Ruoslahti E (February 2000). "R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras". J. Biol. Chem. (UNITED STATES) 275 (7): 5222–7. doi:10.1074/jbc.275.7.5222. ISSN 0021-9258. PMID 10671570. 
  5. ^ Fernandez-Sarabia, M J; Bischoff J R (November 1993). "Bcl-2 associates with the ras-related protein R-ras p23". Nature (ENGLAND) 366 (6452): 274–5. doi:10.1038/366274a0. ISSN 0028-0836. PMID 8232588. 
  6. ^ Yuryev, Anton; Wennogle Lawrence P (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics (United States) 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. ISSN 0888-7543. PMID 12620389. 
  7. ^ Yuryev, A; Ono M; Goff S A; Macaluso F; Wennogle L P (July 2000). "Isoform-specific localization of A-RAF in mitochondria". Mol. Cell. Biol. (UNITED STATES) 20 (13): 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. ISSN 0270-7306. PMC 85938. PMID 10848612. 
  8. ^ Spaargaren, M; Bischoff J R (December 1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (26): 12609–13. doi:10.1073/pnas.91.26.12609. ISSN 0027-8424. PMC 45488. PMID 7809086. 

Further reading[edit]