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Related RAS viral (r-ras) oncogene homolog 2
Protein RRAS2 PDB 2ery.png
PDB rendering based on 2ery.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RRAS2 ; TC21
External IDs OMIM600098 MGI1914172 HomoloGene6945 GeneCards: RRAS2 Gene
RNA expression pattern
PBB GE RRAS2 212589 at tn.png
PBB GE RRAS2 208456 s at tn.png
PBB GE RRAS2 212590 at tn.png
More reference expression data
Species Human Mouse
Entrez 22800 66922
Ensembl ENSG00000133818 ENSMUSG00000055723
UniProt P62070 P62071
RefSeq (mRNA) NM_001102669 NM_025846
RefSeq (protein) NP_001096139 NP_080122
Location (UCSC) Chr 11:
14.3 – 14.39 Mb
Chr 7:
114.05 – 114.12 Mb
PubMed search [1] [2]

Ras-related protein R-Ras2 is a protein that in humans is encoded by the RRAS2 gene.[1][2][3]


RRAS2 has been shown to interact with C-Raf.[4][5]


  1. ^ Drivas GT, Shih A, Coutavas E, Rush MG, D'Eustachio P (May 1990). "Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line". Mol Cell Biol 10 (4): 1793–8. PMC 362288. PMID 2108320. 
  2. ^ Chan AM, Miki T, Meyers KA, Aaronson SA (September 1994). "A human oncogene of the RAS superfamily unmasked by expression cDNA cloning". Proc Natl Acad Sci U S A 91 (16): 7558–62. doi:10.1073/pnas.91.16.7558. PMC 44441. PMID 8052619. 
  3. ^ "Entrez Gene: RRAS2 related RAS viral (r-ras) oncogene homolog 2". 
  4. ^ Li, W; Han M; Guan K L (April 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes Dev. (UNITED STATES) 14 (8): 895–900. ISSN 0890-9369. PMC 316541. PMID 10783161. 
  5. ^ Movilla, N; Crespo P; Bustelo X R (October 1999). "Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins". Oncogene (ENGLAND) 18 (43): 5860–9. doi:10.1038/sj.onc.1202968. ISSN 0950-9232. PMID 10557073. 

Further reading[edit]