RRM2

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Ribonucleotide reductase M2
PDB 1h0o EBI.jpg
PDB rendering based on 1h0o.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RRM2 ; R2; RR2; RR2M
External IDs OMIM180390 MGI98181 HomoloGene20277 ChEMBL: 1954 GeneCards: RRM2 Gene
EC number 1.17.4.1
Orthologs
Species Human Mouse
Entrez 6241 20135
Ensembl ENSG00000171848 ENSMUSG00000020649
UniProt P31350 P11157
RefSeq (mRNA) NM_001034 NM_009104
RefSeq (protein) NP_001025 NP_033130
Location (UCSC) Chr 2:
10.26 – 10.27 Mb
Chr 12:
24.71 – 24.71 Mb
PubMed search [1] [2]

Ribonucleoside-diphosphate reductase subunit M2, also known as ribonucleotide reductase small subunit, is an enzyme that in humans is encoded by the RRM2 gene.[1][2]

Function[edit]

This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini.[1]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article
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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article
|{{{bSize}}}px|alt=Fluorouracil (5-FU) Activity edit|]]
Fluorouracil (5-FU) Activity edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601". 

References[edit]

  1. ^ a b "Entrez Gene: ribonucleotide reductase M2". 
  2. ^ Pavloff N, Rivard D, Masson S, Shen SH, Mes-Masson AM (1992). "Sequence analysis of the large and small subunits of human ribonucleotide reductase". DNA Seq. 2 (4): 227–34. doi:10.3109/10425179209020807. PMID 1627826. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.