RSF1

Remodeling and spacing factor 1
Identifiers
Symbols	RSF1; HBXAP; RSF-1; XAP8; p325
External IDs	OMIM: 608522 MGI: 2682305 HomoloGene: 41142 GeneCards: RSF1 Gene
Gene Ontology Molecular function • protein binding • zinc ion binding • ATPase activity • histone binding • metal ion binding Cellular component • nucleus • RSF complex Biological process • nucleosome assembly • nucleosome assembly • chromatin remodeling • transcription initiation, DNA-dependent • nucleosome positioning • CenH3-containing nucleosome assembly at centromere • negative regulation of DNA binding • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • positive regulation of viral transcription Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51773	233532
Ensembl	ENSG00000048649	ENSMUSG00000035623
UniProt	Q96T23	n/a
RefSeq (mRNA)	NM_016578	NM_001081267.2
RefSeq (protein)	NP_057662	NP_001074736.1
Location (UCSC)	Chr 11: 77.37 – 77.53 Mb	Chr 7: 104.73 – 104.84 Mb
PubMed search	[1]	[2]

Remodeling and spacing factor 1 is a protein that in humans is encoded by the RSF1 gene.

HBXAP is involved in transcription repression, transcription coactivation when associated with hepatitis B virus X protein (HBX), and chromatin remodeling and spacing when associated with SNF2H (MIM 603375).[supplied by OMIM]

Further reading

• Lee TH, Elledge SJ, Butel JS (1995). "Hepatitis B virus X protein interacts with a probable cellular DNA repair protein.". J. Virol. 69 (2): 1107–14. PMC 188683. PMID 7815490. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=188683. 
• LeRoy G, Orphanides G, Lane WS, Reinberg D (1998). "Requirement of RSF and FACT for transcription of chromatin templates in vitro.". Science 282 (5395): 1900–4. doi:10.1126/science.282.5395.1900. PMID 9836642. 
• Shamay M, Barak O, Shaul Y (2002). "HBXAP, a novel PHD-finger protein, possesses transcription repression activity.". Genomics 79 (4): 523–9. doi:10.1006/geno.2002.6717. PMID 11944984. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.". Genes Cells 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. 
• Huang JY, Shen BJ, Tsai WH, Lee SC (2004). "Functional interaction between nuclear matrix-associated HBXAP and NF-kappaB.". Exp. Cell Res. 298 (1): 133–43. doi:10.1016/j.yexcr.2004.04.019. PMID 15242768. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Shih IeM, Sheu JJ, Santillan A, et al. (2005). "Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma.". Proc. Natl. Acad. Sci. U.S.A. 102 (39): 14004–9. doi:10.1073/pnas.0504195102. PMC 1236547. PMID 16172393. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1236547. 
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. 
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.