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R-spondin 3
External IDs OMIM610574 MGI1920030 HomoloGene12484 GeneCards: RSPO3 Gene
Species Human Mouse
Entrez 84870 72780
Ensembl ENSG00000146374 ENSMUSG00000019880
UniProt Q9BXY4 Q2TJ95
RefSeq (mRNA) NM_032784 NM_028351
RefSeq (protein) NP_116173 NP_082627
Location (UCSC) Chr 6:
127.44 – 127.52 Mb
Chr 10:
29.45 – 29.54 Mb
PubMed search [1] [2]

R-spondin-3 is a protein that in humans is encoded by the RSPO3 gene.[1][2][3]

This gene encodes a member of the thrombospondin type 1 repeat supergene family. In addition, the protein contains a furin-like cysteine-rich region. Furin-like repeat domains have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases.[3]


  1. ^ Adams JC, Tucker RP (Aug 2000). "The thrombospondin type 1 repeat (TSR) superfamily: diverse proteins with related roles in neuronal development". Dev Dyn 218 (2): 280–99. doi:10.1002/(SICI)1097-0177(200006)218:2<280::AID-DVDY4>3.0.CO;2-0. PMID 10842357. 
  2. ^ Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, Wu W (Oct 2004). "R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis". Dev Cell 7 (4): 525–34. doi:10.1016/j.devcel.2004.07.019. PMID 15469841. 
  3. ^ a b "Entrez Gene: RSPO3 R-spondin 3 homolog (Xenopus laevis)". 

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