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Symbol RTKN
External IDs OMIM602288 MGI107371 HomoloGene7522 GeneCards: RTKN Gene
Species Human Mouse
Entrez 6242 20166
Ensembl ENSG00000114993 ENSMUSG00000034930
UniProt Q9BST9 Q8C6B2
RefSeq (mRNA) NM_001015055 NM_001136227
RefSeq (protein) NP_001015055 NP_001129699
Location (UCSC) Chr 2:
74.65 – 74.67 Mb
Chr 6:
83.14 – 83.15 Mb
PubMed search [1] [2]

Rhotekin is a protein that in humans is encoded by the RTKN gene.[1][2][3]

This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.[3]


  1. ^ Jang W, Weber JS, Harkins EB, Meisler MH (May 1997). "Localization of the rhotekin gene RTKN on the physical maps of mouse chromosome 6 and human chromosome 2p13 and exclusion as a candidate for mnd2 and LGMD2B". Genomics 40 (3): 506–7. doi:10.1006/geno.1996.4593. PMID 9073523. 
  2. ^ Reynaud C, Fabre S, Jalinot P (Nov 2000). "The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element". J Biol Chem 275 (43): 33962–8. doi:10.1074/jbc.M000465200. PMID 10940294. 
  3. ^ a b "Entrez Gene: RTKN rhotekin". 

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