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Reticulon 2
Symbols RTN2 ; NSP2; NSPL1; NSPLI; SPG12
External IDs OMIM603183 MGI107612 HomoloGene32180 GeneCards: RTN2 Gene
RNA expression pattern
PBB GE RTN2 34408 at tn.png
PBB GE RTN2 204217 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6253 20167
Ensembl ENSG00000125744 ENSMUSG00000030401
UniProt O75298 O70622
RefSeq (mRNA) NM_005619 NM_001025364
RefSeq (protein) NP_005610 NP_001020535
Location (UCSC) Chr 19:
45.99 – 46 Mb
Chr 7:
19.28 – 19.3 Mb
PubMed search [1] [2]

Reticulon-2 is a protein that in humans is encoded by the RTN2 gene.[1][2][3]

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]


  1. ^ Stubbs L, Carver EA, Shannon ME, Kim J, Geisler J, Generoso EE, Stanford BG, Dunn WC, Mohrenweiser H, Zimmermann W, Watt SM, Ashworth LK (Dec 1996). "Detailed comparative map of human chromosome 19q and related regions of the mouse genome". Genomics 35 (3): 499–508. doi:10.1006/geno.1996.0390. PMID 8812484. 
  2. ^ Geisler JG, Stubbs LJ, Wasserman WW, Mucenski ML (May 1998). "Molecular cloning of a novel mouse gene with predominant muscle and neural expression". Mamm Genome 9 (4): 274–82. doi:10.1007/s003359900748. PMID 9530622. 
  3. ^ a b "Entrez Gene: RTN2 reticulon 2". 

Further reading[edit]