RU-58841

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RU-58841
RU-58841.svg
Systematic (IUPAC) name
4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile
Clinical data
Legal status
?
Identifiers
CAS number 154992-24-2
ATC code ?
PubChem CID 132981
Chemical data
Formula C17H18F3N3O3 
Mol. mass 369.3 g/mol

RU-58841 is an experimental drug candidate which is intended for use as a topical treatment for acne, androgenetic alopecia, and hirsutism.[1][2] The compound is similar in structure to RU-58642 but contains a different side-chain.[3] These compounds are non-steroidal anti-androgen drugs similar to nilutamide,[4] which is related to flutamide and bicalutamide. A more recent drug is called enzalutamide.

References[edit]

  1. ^ Battmann, Bonfils A, Branche C, Humbert J, Goubet F, Teutsch G, Philibert D (January 1994). "RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism". Journal of Steroid Biochemistry and Molecular Biology 48 (1): 55–60. doi:10.1016/0960-0760(94)90250-x. PMID 8136306. 
  2. ^ Münster U, Nakamura C, Haberland A, Jores K, Mehnert W, Rummel S, Schaller M, Korting HC, Zouboulis ChC, Blume-Peytavi U, Schäfer-Korting M (January 2005). "RU 58841-myristate--prodrug development for topical treatment of acne and androgenetic alopecia". Pharmazie 60 (1): 8–12. PMID 15700772. 
  3. ^ Van Dort ME, Jung YW (2001). "Synthesis and structure–activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands". Bioorg. Med. Chem. Lett. 11 (8): 1045–1047. doi:10.1016/s0960-894x(01)00146-9. PMID 11327585. 
  4. ^ "Investigational medications in the treatment of alopecia". Expert Opinion on Investigational Drugs 14 (2): 177–184. February 2005. doi:10.1517/13543784.14.2.177.