RUNX1T1

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Runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
Protein RUNX1T1 PDB 1wq6.png
PDB rendering based on 1wq6.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RUNX1T1 ; AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2
External IDs OMIM133435 MGI104793 HomoloGene3801 GeneCards: RUNX1T1 Gene
RNA expression pattern
PBB GE RUNX1T1 205529 s at tn.png
PBB GE RUNX1T1 205528 s at tn.png
PBB GE RUNX1T1 216831 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 862 12395
Ensembl ENSG00000079102 ENSMUSG00000006586
UniProt Q06455 Q61909
RefSeq (mRNA) NM_001198625 NM_001111026
RefSeq (protein) NP_001185554 NP_001104496
Location (UCSC) Chr 8:
92.97 – 93.12 Mb
Chr 4:
13.74 – 13.89 Mb
PubMed search [1] [2]

Protein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene.[1][2][3]

The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.[3]

Interactions[edit]

RUNX1T1 has been shown to interact with CBFA2T2,[4][5][6] Zinc finger and BTB domain-containing protein 16,[7][8] Nuclear receptor co-repressor 1,[9][10] Nuclear receptor co-repressor 2,[10][11] CBFA2T3,[5][6] GFI1,[12] Calcitriol receptor[13] and PRKAR2A.[14]

References[edit]

  1. ^ Erickson P, Gao J, Chang KS, Look T, Whisenant E, Raimondi S, Lasher R, Trujillo J, Rowley J, Drabkin H (October 1992). "Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt". Blood 80 (7): 1825–31. PMID 1391946. 
  2. ^ Calabi F, Cilli V (Dec 1998). "CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family". Genomics 52 (3): 332–341. doi:10.1006/geno.1998.5429. PMID 9790752. 
  3. ^ a b "Entrez Gene: RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)". 
  4. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514. 
  5. ^ a b Lindberg, Sofia Rondin; Olsson André, Persson Ann-Maj, Olsson Inge (Dec 2003). "Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins". Eur. J. Haematol. (Denmark) 71 (6): 439–447. doi:10.1046/j.0902-4441.2003.00166.x. ISSN 0902-4441. PMID 14703694. 
  6. ^ a b Hoogeveen, André T; Rossetti Stefano, Stoyanova Violeta, Schonkeren Joris, Fenaroli Angelia, Schiaffonati Luisa, van Unen Leontine, Sacchi Nicoletta (September 2002). "The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies". Oncogene (England) 21 (43): 6703–6712. doi:10.1038/sj.onc.1205882. ISSN 0950-9232. PMID 12242670. 
  7. ^ Melnick, A M; Westendorf J J, Polinger A, Carlile G W, Arai S, Ball H J, Lutterbach B, Hiebert S W, Licht J D (March 2000). "The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein". Mol. Cell. Biol. (UNITED STATES) 20 (6): 2075–2086. doi:10.1128/MCB.20.6.2075-2086.2000. ISSN 0270-7306. PMC 110824. PMID 10688654. 
  8. ^ Melnick, A; Carlile G W, McConnell M J, Polinger A, Hiebert S W, Licht J D (Dec 2000). "AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein". Blood (UNITED STATES) 96 (12): 3939–47. ISSN 0006-4971. PMID 11090081. 
  9. ^ Amann, J M; Nip J, Strom D K, Lutterbach B, Harada H, Lenny N, Downing J R, Meyers S, Hiebert S W (October 2001). "ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain". Mol. Cell. Biol. (United States) 21 (19): 6470–6483. doi:10.1128/MCB.21.19.6470-6483.2001. ISSN 0270-7306. PMC 99794. PMID 11533236. 
  10. ^ a b Zhang, J; Hug B A, Huang E Y, Chen C W, Gelmetti V, Maccarana M, Minucci S, Pelicci P G, Lazar M A (January 2001). "Oligomerization of ETO is obligatory for corepressor interaction". Mol. Cell. Biol. (UNITED STATES) 21 (1): 156–163. doi:10.1128/MCB.21.1.156-163.2001. ISSN 0270-7306. PMC 88789. PMID 11113190. 
  11. ^ Takahashi, Shinichiro; McConnell Melanie J, Harigae Hideo, Kaku Mitsuo, Sasaki Takeshi, Melnick Ari M, Licht Jonathan D (June 2004). "The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT". Blood (United States) 103 (12): 4650–4658. doi:10.1182/blood-2003-08-2759. ISSN 0006-4971. PMID 14982881. 
  12. ^ McGhee, Laura; Bryan Josh, Elliott Liza, Grimes H Leighton, Kazanjian Avedis, Davis J Nathan, Meyers Shari (August 2003). "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism". J. Cell. Biochem. (United States) 89 (5): 1005–1018. doi:10.1002/jcb.10548. ISSN 0730-2312. PMID 12874834. 
  13. ^ Puccetti, Elena; Obradovic Darja, Beissert Tim, Bianchini Andrea, Washburn Birgit, Chiaradonna Ferdinando, Boehrer Simone, Hoelzer Dieter, Ottmann Oliver Gerhard, Pelicci Pier Giuseppe, Nervi Clara, Ruthardt Martin (Dec 2002). "AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor". Cancer Res. (United States) 62 (23): 7050–8. ISSN 0008-5472. PMID 12460926. 
  14. ^ Fukuyama, T; Sueoka E, Sugio Y, Otsuka T, Niho Y, Akagi K, Kozu T (September 2001). "MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes". Oncogene (England) 20 (43): 6225–6232. doi:10.1038/sj.onc.1204794. ISSN 0950-9232. PMID 11593431. 

Further reading[edit]