RUNX3

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Runt-related transcription factor 3
Protein RUNX3 PDB 1cmo.png
PDB rendering based on 1cmo.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RUNX3 ; AML2; CBFA3; PEBP2aC
External IDs OMIM600210 MGI102672 HomoloGene37914 GeneCards: RUNX3 Gene
RNA expression pattern
PBB GE RUNX3 204197 s at tn.png
PBB GE RUNX3 204198 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 864 12399
Ensembl ENSG00000020633 ENSMUSG00000070691
UniProt Q13761 Q64131
RefSeq (mRNA) NM_001031680 NM_019732
RefSeq (protein) NP_001026850 NP_062706
Location (UCSC) Chr 1:
25.23 – 25.29 Mb
Chr 4:
135.12 – 135.18 Mb
PubMed search [1] [2]

Runt-related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene.[1]

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-YGYGGT-3' found in a number of enhancers and promoters,[2] and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[3]

In melanocytic cells RUNX3 gene expression may be regulated by MITF.[4]

Knockout mouse[edit]

Runx3 null mouse gastric mucosa exhibits hyperplasia due to stimulated proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to TGF-beta stimulation.[5]

Interactions[edit]

RUNX3 has been shown to interact with TLE1.[6]

See also[edit]

References[edit]

  1. ^ Levanon D, Negreanu V, Bernstein Y, Bar-Am I, Avivi L, Groner Y (February 1995). "AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization". Genomics 23 (2): 425–32. doi:10.1006/geno.1994.1519. PMID 7835892. 
  2. ^ Levanon D, Eisenstein M, Groner Y (April 1998). "Site-directed mutagenesis supports a three-dimensional model of the runt domain.". J Mol Biol. 277 (3): 509–12. doi:10.1006/jmbi.1998.1633. PMID 9533875. 
  3. ^ "Entrez Gene: RUNX3 runt-related transcription factor 3". 
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  5. ^ Li QL, Ito K, Sakakura C, et al. (April 2002). "Causal relationship between the loss of RUNX3 expression and gastric cancer". Cell 109 (1): 113–24. doi:10.1016/S0092-8674(02)00690-6. PMID 11955451. 
  6. ^ Levanon, D; Goldstein R E; Bernstein Y; Tang H; Goldenberg D; Stifani S; Paroush Z; Groner Y (Sep 1998). "Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11590–5. doi:10.1073/pnas.95.20.11590. PMC 21685. PMID 9751710. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.