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RuvB-like AAA ATPase 2
Protein RUVBL2 PDB 2cqa.png
PDB rendering based on 2cqa.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RUVBL2 ; ECP51; INO80J; REPTIN; RVB2; TIH2; TIP48; TIP49B
External IDs OMIM604788 MGI1342299 HomoloGene4856 GeneCards: RUVBL2 Gene
EC number
RNA expression pattern
PBB GE RUVBL2 201459 at tn.png
More reference expression data
Species Human Mouse
Entrez 10856 20174
Ensembl ENSG00000183207 ENSMUSG00000003868
UniProt Q9Y230 Q9WTM5
RefSeq (mRNA) NM_006666 NM_011304
RefSeq (protein) NP_006657 NP_035434
Location (UCSC) Chr 19:
49.5 – 49.52 Mb
Chr 7:
45.42 – 45.44 Mb
PubMed search [1] [2]

RuvB-like 2 (E. coli), also known as RUVBL2, is a human gene coding for a protein belonging to the AAA+ family of proteins.

This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. However, the evidence for whether RUVBL2 has DNA helicase activity is contradictory.[1] This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.[2]


RUVBL2 has been shown to interact with RuvB-like 1[3] and Activating transcription factor 2.[4]


  1. ^ Puri, T; Wendler, P; Sigala, B; Saibil, H; Tsaneva, IR (2007). "Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex". Journal of Molecular Biology 366 (1): 179–92. doi:10.1016/j.jmb.2006.11.030. PMID 17157868. 
  2. ^ "Entrez Gene: RUVBL2 RuvB-like 2 (E. coli)". 
  3. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  4. ^ Cho, S G; Bhoumik A; Broday L; Ivanov V; Rosenstein B; Ronai Z (Dec 2001). "TIP49b, a Regulator of Activating Transcription Factor 2 Response to Stress and DNA Damage". Mol. Cell. Biol. (United States) 21 (24): 8398–413. doi:10.1128/MCB.21.24.8398-8413.2001. ISSN 0270-7306. PMC 100004. PMID 11713276. 

Further reading[edit]