Raclopride

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Raclopride
Raclopride.png
Systematic (IUPAC) name
3,5-dichloro-N-{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-2-hydroxy-6-methoxybenzamide
Clinical data
Legal status
?
Pharmacokinetic data
Half-life 20 min
Identifiers
CAS number 84225-95-6 N
ATC code None
PubChem CID 3033769
IUPHAR ligand 94
ChemSpider 2298373 YesY
UNII 430K3SOZ7G YesY
ChEMBL CHEMBL8809 YesY
Chemical data
Formula C15H20Cl2N2O3 
Mol. mass 347.236 g/mol
 N (what is this?)  (verify)

Raclopride is a synthetic compound that acts as an antagonist on D2 dopamine receptors.[1] It can be radiolabelled with the carbon-11 radioisotope and used in positron emission tomography (PET) scanning to assess the degree of dopamine binding to the D2 Dopamine receptor. For example, one study found decreasing binding with the personality trait detachment.[2] Radiolabelled raclopride is also commonly used to determine the efficacy and neurotoxicity of dopaminergic drugs.

References[edit]

  1. ^ C. Kohler, H. Hall, S. O. Ogren, L. Gawell (July 1985). "Specific in vitro and in vivo binding of 3H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain". Biochemical Pharmacology 34 (13): 2251–2259. doi:10.1016/0006-2952(85)90778-6. PMID 4015674. 
  2. ^ Lars Farde, J. Petter Gustavsson, Erik Jönsson (February 1997). "D2 dopamine receptors and personality traits". Nature 385 (6617): 590. doi:10.1038/385590a0. PMID 9024656. 

External links[edit]