Radixin

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Radixin
Protein RDX PDB 1gc6.png
PDB rendering based on 1gc6.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RDX ; DFNB24
External IDs OMIM179410 MGI97887 HomoloGene37707 GeneCards: RDX Gene
RNA expression pattern
PBB GE RDX 204969 s at tn.png
PBB GE RDX 212397 at tn.png
PBB GE RDX 212398 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5962 19684
Ensembl ENSG00000137710 ENSMUSG00000032050
UniProt P35241 P26043
RefSeq (mRNA) NM_001260492 NM_001104616
RefSeq (protein) NP_001247421 NP_001098086
Location (UCSC) Chr 11:
110.05 – 110.17 Mb
Chr 9:
52.05 – 52.09 Mb
PubMed search [1] [2]

Radixin is a protein that in humans is encoded by the RDX gene.[1][2][3]

Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses.[3]

See also[edit]

Interactions[edit]

Radixin has been shown to interact with GNA13.[4]

References[edit]

  1. ^ Wilgenbus KK, Milatovich A, Francke U, Furthmayr H (June 1993). "Molecular cloning, cDNA sequence, and chromosomal assignment of the human radixin gene and two dispersed pseudogenes". Genomics 16 (1): 199–206. doi:10.1006/geno.1993.1159. PMID 8486357. 
  2. ^ Khan SY, Ahmed ZM, Shabbir MI, Kitajiri S, Kalsoom S, Tasneem S, Shayiq S, Ramesh A, Srisailpathy S, Khan SN, Smith RJ, Riazuddin S, Friedman TB, Riazuddin S (April 2007). "Mutations of the RDX gene cause nonsyndromic hearing loss at the DFNB24 locus". Hum Mutat 28 (5): 417–23. doi:10.1002/humu.20469. PMID 17226784. 
  3. ^ a b "Entrez Gene: RDX radixin". 
  4. ^ Vaiskunaite, R; Adarichev V, Furthmayr H, Kozasa T, Gudkov A, Voyno-Yasenetskaya T A (August 2000). "Conformational activation of radixin by G13 protein alpha subunit". J. Biol. Chem. (UNITED STATES) 275 (34): 26206–12. doi:10.1074/jbc.M001863200. ISSN 0021-9258. PMID 10816569. 

Further reading[edit]