Neal's first album, called Louisiana Legend, was initially issued by King Snake Records and later by Alligator Records in 1990. His 1991 album I Been Mistreated was released on Ichiban Records. Neal toured globally. In 1997 his harmonica playing was featured on the album Live: Swampland Jam by Tab Benoit. Neal's album Old Friends was issued in 1998.
Neal died of cancer in Baton Rouge in September 2004. Nine of his ten children are also blues musicians, and several performed with him on his later releases on the Alligator label.