Historically, Ramaytush language territory was largely bordered by ocean and sea, except in the south where they bordered the people of the Santa Clara Valley who spoke the Tamyen language Ohlone and the people of the Santa Cruz Mountains and Pacific Coast at Point Año Nuevo who spoke dialects merging toward the Awaswas language. To the east, across San Francisco Bay, were tribes that spoke the Chochenyo Ohlone language. To the north, across the Golden Gate, was the Huimen local tribe of Coast Miwok language speakers. The northernmost Ramaytush local tribe, the Yelamu of San Francisco, were intermarried with the Huchiun Chochenyos of the Oakland area at the time of Spanish colonization.
European disease took a heavy toll of life on all tribal people who came to Mission Dolores after its creation in 1776. The Ohlone people were forced to use Spanish resulting in the loss of their language. Hundreds of Ohlone people at Mission Dolores were taken to the north bay to construct Mission San Rafael which was then used as a hospital for sick neophytes. Alfred L. Kroeber claimed that the west bay people were extinct by 1915. The Muwekma Ohlone Tribe, descendants of closely related Chochenyo and Tamyen Ohlone speakers, have been vocal advocates for Native American issues on the San Francisco Peninsula, as have some Ohlone descendants from the Monterey Bay Area farther south.