Ramoplanin
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| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ℞-only (US) |
| Routes | Oral |
| Identifiers | |
| CAS number | 76168-82-6  |
| ATC code | None |
| PubChem | CID 16132338 |
| UNII | 0WX9996O2G  |
| ChEMBL | CHEMBL1095892 |
| Chemical data | |
| Formula | C106H170ClN21O30 |
| Mol. mass | 2254.05 g/mol |
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Ramoplanin (INN) is a glycolipodepsipeptide antibiotic drug derived from strain ATCC 33076 of Actinoplanes.[1]
[edit] Mechanism
It exerts its bacteriocidal effect by inhibiting cell wall biosynthesis, acting by inhibiting the transglycosylation step of peptidoglycan synthesis.[2]
[edit] Uses
Its development has been fast-tracked by the U.S. Food and Drug Administration as a treatment for multiantibiotic-resistant Clostridium difficile infection of the gastrointestinal tract,[3] although it is unstable in the bloodstream and so can be taken only orally against GI tract infections.[4][5][6]
[edit] References
- ^ Farver DK, Hedge DD, Lee SC. Ramoplanin: a lipoglycodepsipeptide antibiotic. Annals of Pharmacotherapy. 2005 May;39(5):863-8. PMID 15784805
- ^ Fang X, Tiyanont K, Zhang Y, Wanner J, Boger D, Walker S. The mechanism of action of ramoplanin and enduracidin. Molecular Biosystems. 2006 Jan;2(1):69-76. PMID 16880924
- ^ Fulco P, Wenzel RP. Ramoplanin: a topical lipoglycodepsipeptide antibacterial agent. Expert Review of Anti Infective Therapy. 2006 Dec;4(6):939-45. PMID 17181409
- ^ Scheinfeld N. A comparison of available and investigational antibiotics for complicated skin infections and treatment-resistant Staphylococcus aureus and enterococcus. Journal of Drugs in Dermatology. 2007 Jan;6(1):97-103. PMID 17373167
- ^ Balagopal A, Sears CL. Clostridium difficile: new therapeutic options. Current Opinion in Pharmacology. 2007 Oct;7(5):455-8. PMID 17644040
- ^ Gerding DN, Muto CA, Owens RC Jr. Treatment of Clostridium difficile infection. Clinical Infectious Diseases. 2008 Jan 15;46 Suppl 1:S32-42. PMID 18177219
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