Rampla Juniors were founded in the Aduana area, (also the birthplace of River Plate FC), then moved first to the Aguada neighbourhood, and finally, around 1920, to the Cerro neighborhood. Their colours are taken from Fortaleza, a club that existed in the early years of Rampla's stint in the Cerro area. Another story of how they chose their colours, is similar to how Boca Juniors supposedly got the idea for their kit colors from a Swedish flag on a ship. It is rumored that Rampla's founders took the red and green from an Italian flag on a ship that arrived in Montevideo Bay. It is also said that the basketball team C.A. Aguada (founded in 1922) took their colours from Rampla Juniors.
Rampla's most famous supporter is Natalia Oreiro. Rampla in 1927 won the Uruguayan Primera División, the 1927 Squad was: Pedro Arispe (Captain), Pedro Aguirre, Enrique Ballestrero, Pedro Cabrera, Julio Nieto y José Magallanes, Juan Miguel Labraga, Luis Gaitán, Conrado Haeberli, Vital Ruffatti and Conrado Bidegain.
Rampla was once called the third "big" (meaning popular or best) of Uruguay's clubs, Peñarol and Nacional being first and second, due to the huge amount of followers and positive results. In 2007, Rampla finished tied in 2nd place with Danubio F.C. in the Uruguayan 1st division. Their team record was (9 wins, 4 draws, and 2 losses, in 15 games).