Sir William Jones bought the estate at Ramsbury in Wiltshire, on the River Kennet between Hungerford and Marlborough in 1676. He wanted a country house to match his status, and turned to Dr Robert Hooke as one of the leading architects of the day, who he already knew from work that Hooke had supervised on Jones' house in Bloomsbury. Hooke met Jones at least five times in 1681, and probably provided him with designs for Ramsbury Manor at that time. Construction of the house probably began in 1681, but the house was unfinished when Sir William Jones died in May 1682. The main structure of the house was completed in 1683, but work on the interior continued until 1686. The house is an excellent example of Hooke’s country house style or architecture, dignified and built to the best standards of the time.
In 1965 the house was sold with 460 acres of land to an American property dealer for £650,000, causing the Guinness Book of Records for 1966 to describe it as "the most expensive house in Britain".
Ramsbury Manor is now the home of the property tycoon Harry Hyams.
On 1 February 2006 the house was the scene of a major burglary by the Johnson Gang. The gang was caught and convicted, with the prosecutor Paul Reid stating that "This has been described as the most valuable domestic burglary ever committed in this country. The collection is described as priceless. There is a difficulty in putting a value on antiques and antiquities – some of them very precious and very rare – but it is tens of millions of pounds." In August 2008 the gang received long prison sentences.
- Inwood, Stephen (2011-02-28). The Man Who Knew Too Much (Kindle Locations 5864-5867). Macmillan Publishers UK. Kindle Edition.
- Inwood, Stephen (2011-02-28). The Man Who Knew Too Much (Kindle Locations 6330-6331). Macmillan Publishers UK. Kindle Edition.
- "Timeline of Johnson gangs raids". London: Telegraph.co.uk. 6 August 2008.
- "BBC news report 6 August 2008 - five jailed for biggest burglary". BBC News. 2008-08-06.
- Jones, Sam (7 August 2008). "The Guardian 7 August 2008 - After 20 years, five police forces and £80m in loot, Britain's biggest crime family brought to justice". London.
- "Five jailed for biggest burglary - BBC News". 2008-08-06. Retrieved 2008-08-06.
- McGinty, Stephen (7 August 2008). "Family gang who stole £80m from 'lords and ladies' jailed for 49 years". Edinburgh: Scotsman.com.