There are more than a hundred proteins in the Ras superfamily. Based on structure, sequence and function, the Ras superfamily is divided into nine main families, each of which further divided into subfamilies: Ras, Rad, Rab, Rap, Ran, Rho, Rheb, Rit, and Arf. Miro is a recent contributor to the superfamily.
Each subfamily shares the common core G domain, which provides essential GTPase and nucleotide exchange activity.
The surrounding sequence helps determine the functional specificity of the small GTPase, for example the 'Insert Loop', common to the Rho subfamily, specifically contributes to binding to effector proteins such as IQGAP and WASP.
Subfamilies and members
The following is a list of human proteins belonging to the Ras superfamily:
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