He was born in 1926 and attended school in Wembley. He studied physics at University College London from 1944 to 1947 and became a hospital physicist at the King’s Fund and Middlesex Hospital between 1947 and 1949 before joining King's College London as a research student.
Work at King's and DNA
At King's College London, Gosling worked on X-ray diffraction with Maurice Wilkins, analyzing samples of DNA which they prepared by hydrating and drawing out into thin filaments and photographing in a hydrogen atmosphere.
Gosling was then assigned to Rosalind Franklin when she joined King's College London in 1951. They worked under the direction of Sir John Randall. Together they produced the first X-ray diffraction photographs of the "form B" paracrystalline arrays of highly hydrated DNA. She was his academic supervisor. During the next two years, the pair worked closely together to perfect the technique of x-ray diffraction photography of DNA and obtained at the time the sharpest diffraction images of DNA. Gosling claimed to have made the X-ray diffraction image of DNA known as "Photograph 51." Rosalind Franklin actually made this photograph. This work led directly to the 1962 Nobel Prize for Physiology or Medicine being awarded to Francis Crick, James D. Watson and Maurice Wilkins. Gosling was the co-author with Franklin of one of the three DNA double helix papers published in Nature in April 1953.
His other KCL colleagues included Alex Stokes and Herbert Wilson. He described himself as "a slave in chains" when working for Rosalind Franklin, having previously worked for Maurice Wilkins, on DNA.
Gosling briefly remained at King's College London following the completion of his thesis in 1954 before lecturing in physics at Queen’s College, University of St Andrews, and at the University of the West Indies.
Work at Guy's Hospital
He returned to the UK in 1967 and became Lecturer and Reader at Guy's Hospital Medical School, and Professor and Emeritus Professor in Physics Applied to Medicine from 1984. Here he helped develop the underlying basic medical science and technology for haemodynamic doppler ultrasound vascular assessment in the Non Invasive Angiology Group, and set up the clinical Ultrasonic Angiology Unit.
References and sources
- "King's College biography". Retrieved 2006-11-29.
- Wilkins, M.; Gosling, R.; Seeds, W. (1951). "Physical studies of nucleic acid". Nature 167 (4254): 759–760. Bibcode:1951Natur.167..759W. doi:10.1038/167759a0. PMID 14833383.
- Gosling, R.; Tickle, C.; Running, S. W.; Tandong, Y.; Dinnyes, A.; Osowole, A. A.; Cule, E. (2011). "Seven ages of the PhD". Nature 472 (7343): 283–286. doi:10.1038/472283a.
- Franklin, R. E.; Gosling, R. G. (1953). "Molecular Configuration in Sodium Thymonucleate". Nature 171 (4356): 740–741. doi:10.1038/171740a0. PMID 13054694.
- Side, C. D.; Gosling, R. G. (1971). "Non-surgical Assessment of Cardiac Function". Nature 232 (5309): 335–336. Bibcode:1971Natur.232..335S. doi:10.1038/232335a0. PMID 5094838.
- Laogun, A. A.; Gosling, R. G. (1982). "In vivo arterial compliance in man". Clinical Physics and Physiological Measurement 3 (3): 201–212. Bibcode:1982CPPM....3..201L. doi:10.1088/0143-0815/3/3/004. PMID 7140158.
- Kontis, S.; Gosling, R. G. (1987). "A computerized method for processing of spectrally analysed Doppler-shifted signals from insonated arteries". Journal of Medical Engineering & Technology 11 (3): 108–112. doi:10.3109/03091908709018151.
- Baskett, J. J.; Lewis, R. R.; Beasley, M. G.; Gosling, R. G. (1990). "Changes in Carotid Artery Compliance with Age". Age and Ageing 19 (4): 241–246. doi:10.1093/ageing/19.4.241. PMID 2220482. - Abstract
- Detailed interview 2013 in Genome Biology
- Raymond Gosling in The King's story
- Doppler-shifted ultrasound units (1974-1981) jointly developed by Dr.B.A.Coghlan and Prof.R.G.Gosling's Blood Flow Group at the Physics Dept., Guy's Hospital Medical School, London. These early devices were used for haemodynamic assessment of normal volunteers and assessment of patients with peripheral vascular disease. The work reflects a close and extensive collaboration with Dr.M.G.Taylor.