According to Sully Erna, the song is about how every time he tours to New Orleans with Godsmack, he gets sick. Sully attributes this to having been killed in New Orleans in a previous life and being haunted by "evil spirits" every time he visits New Orleans.
There are two versions of Re-Align. The original version appeared on Godsmack's third studio album, Faceless. The second version, which is an acoustic recording, appeared on The Other Side EP. Although the two versions have a similar sound, the acoustic version runs for 4:23, three seconds longer than the original version. The acoustic version is, naturally, a bit softer.