Gameplay in the game is similar to that of the previous game. The more big hits the player land consecutively, letters that spell out "RUMBLE" appear below the player's side of the screen. Letters also appear when the fighter taunts his opponent. Once the word is formed, powerful combo attacks can be activated that will almost definitely knock the opponent down. This time, however, there are three levels of "RUMBLE", which build up one after the other. If the player successfully lands a combo with his RUMBLE Meter full on the third level (where the letters start smoking), the final blow can launch the opponent clear out of the ring, giving the player an instant victory.
Michael Jackson allowed for his likeness to be used for the game.
News from Midway's sequel to Ready 2 Rumble Boxing were first made public back in early summer of 1999. In May 2000, showed of the game at that year's E3 for demonstration. It was here the Midway announced that the game would receive a PlayStation 2 release. In September 2000 the game was previewed for public demonstrating at that year's ECTS. That same month images and screenshots of two of the game's secret characters were unveiled: Shaquille O'Neal and Michael Jackson. It was stated that Jackson was motion captured and digitally photographed for his character. Midway released the PlayStation 2 version on October 23 to coincide with the release of the PlayStation 2. As with the previous game, Michael Buffer appears in the game as himself. The game's roster also features the then U.S. PresidentBill Clinton and his wife Hillary Rodham Clinton, credited respectively only as "Mr. President" and "The First Lady".
^IGN Staff (October 24, 2000). "Midway Releases Ready 2 Rumble Round 2 So let's get it on! Er, wait, wrong catchphrase... Hey! Look! It's Michael Jackson!". IGN. "The big draw of Ready 2 Rumble Round 2 is the chance to clash with the King of Pop himself, Michael Jackson, who was motion-captured and digitally photographed for his role."Missing or empty |url= (help);|accessdate= requires |url= (help)
^IGN Staff (October 24, 2000). "Midway Releases Ready 2 Rumble Round 2 So let's get it on! Er, wait, wrong catchphrase... Hey! Look! It's Michael Jackson!". IGN. "Midway Sports Asylum have released Ready 2 Rumble Boxing: Round 2 in preparation for the PlayStation 2's launch."Missing or empty |url= (help);|accessdate= requires |url= (help)