The Wood–Ljungdahl pathway is a set of biochemical reactions used by some bacteria and archaea. It is also known as the reductive acetyl–CoA pathway. This pathway enables certain organisms to use hydrogen as an electron donor and carbon dioxide as an electron acceptor as well as a building block for biosynthesis.
In this pathway carbon dioxide is reduced to carbon monoxide, which is then converted to acetyl coenzyme A. Two enzymes participate, CO Dehydrogenase and acetyl-CoA synthase. The former catalyzes the reduction of the CO2 and the latter combines the resulting CO with a methyl group to give acetyl CoA.
- Stephen W. Ragsdale "Metals and Their Scaffolds To Promote Difficult Enzymatic Reactions" Chem. Rev. 2006, 106, 3317–3337. doi:10.1021/cr0503153
- Paul A. Lindahl "Nickel-Carbon Bonds in Acetyl-Coenzyme A Synthases/Carbon Monoxide Dehydrogenases" Met. Ions Life Sci. 2009, volume 6, pp. 133–150. doi:10.1039/9781847559159-00133
- Matschiavelli, N.; Oelgeschlager, E.; Cocchiararo, B.; Finke, J.; Rother, M. (2012). "Function and regulation of isoforms of carbon monoxide dehydrogenase/acetyl-CoA synthase in Methanosarcina acetivorans". Journal of Bacteriology 194 (19): 5377–87. doi:10.1128/JB.00881-12 (inactive 2014-08-04). PMID 22865842.
- Wood HG (February 1991). "Life with CO or CO2 and H2 as a source of carbon and energy". FASEB J. 5 (2): 156–63. PMID 1900793.
- Diekert G, Wohlfarth G (1994). "Metabolism of homoacetogens". Antonie Van Leeuwenhoek 66 (1–3): 209–21. doi:10.1007/BF00871640. PMID 7747932.
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