Khan started her film career starring in Javed Fazil’s Bulandi in 1990.
Khan's early films included Zherilay, Ishq, Naag Devta, Pyar hi pyar, Sailab, Dil, Aag, Shama and Sahiba.
These were followed by films such as Hina, Anjuman, Chakuri, Chandni, Neelam and Insaniat. Later she appeared in Hathi Meray Sathi directed by Shameem Ara and in Rani Beti Raj Karegi directed by Altaf Hussain.
In 2002, Asif Ali Pota’s Fire and Samina Peerzada’s Shararat were released.
She was the first Pakistani actress to be signed by Pepsi Co., Pakistan for their series of advertisements. She has now become an official partner of the Lahore zoo.
Reema Khan married American cardiologist surgeon S. Tariq Shahab on November 16, 2011 in Virginia. The nikkah took place at a local court in Virginia according to American law while Rukhsati took place on November 18, 2011. Her Walima was held in Pearl Continental Hotel Lahore on 27th May , 2012.
Her debut film as a director and producer, Koi Tujh Sa Kahan, was released in Pakistan and overseas. It went on to win the Best Film award at the Lux Style Awards in 2006. Khan won the award for the Best Actress and Best Director for the same film while Moammar Rana won the Best Actor Award.