Renal oncocytoma

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Renal oncocytoma
Classification and external resources
Renal oncocytoma3.jpg
Micrograph of a renal oncocytoma.
ICD-O: M8290/0
DiseasesDB 31956
Renal oncocytoma of the right kidney at CT.

A renal oncocytoma is a tumour of the kidney made up of oncocytes, a special kind of cell.[1][2]

Presentation[edit]

An oncocytoma is an epithelial tumor composed of oncocytes, large eosinophilic cells having small, round, benign-appearing nuclei with large nucleoli with excessive amounts of mitochondria.

Pathophysiology[edit]

Renal oncocytoma is thought to arise from the intercalated cells of collecting ducts of the kidney. It represent 5% to 15% of surgically resected renal neoplasms. Ultrastructurally, the eosinophilic cells have numerous mitochondria.

Diagnosis[edit]

Gross appearance of a renal oncocytoma (left of image) and a slice of a normal kidney (right of image). Note the rounded contour, the mahogany colour and the central scar.

In gross appearance, the tumors are tan or mahogany brown, well circumscribed and contain a central scar. They may achieve a large size (up to 12 cm in diameter).

The main differential diagnosis of renal oncocytoma is chromophobe renal cell carcinoma oncocytic variant, which like the renal oncocytoma has eosinophilic cytoplasm, but has perinuclear clearing and, typically, some degree of nuclear atypia.

Immunohistochemical profile[edit]

[3]

Symptoms[edit]

Most cases of renal oncocytomas are asymptomatic, discovered incidentally (by chance) on a tomography or ultrasound of the abdomen. Some of the possible symptoms are: hematuria, flank pain, abdominal mass.

Treatment[edit]

Renal oncocytoma is considered benign, cured by nephrectomy. There are some familial cases in which these tumors are multicentric rather than solitary.[4] However, they may be resected to exclude a malignant tumor, e.g. renal cell carcinoma.

See also[edit]

Additional images[edit]

References[edit]

  1. ^ Coburn V, Radfar A, Snook D, Mahalingam M (2007). "Cutaneous oncocytoma - a report of three cases and review of the literature". J. Cutan. Pathol. 34 (4): 355–9. doi:10.1111/j.1600-0560.2006.00620.x. PMID 17381809. 
  2. ^ "Atlas of Genetics and Cytogenetics in Oncology and Haematology - Thyroid:oncocytic tumors". Retrieved 2009-02-01. 
  3. ^ [Renal Neoplasms: An Update on Immunohistochemical and Histochemical Features http://www.dako.com/08066_12may10_webchapter26.pdf]
  4. ^ Robbins pathology, page 1015[full citation needed]