Galasso reportedly began her business in the early 1970s as a way to pay for college. She purchased individual packs of cards, primarily Topps, and built sets for sale, which was unusual for that time (the first verifiable complete sets sold were in the 1974 J.C. Penney catalog).
Galasso eventually opened a shop around 1975 on Bay Ridge Pkwy, and later relocated to 6305 10th Avenue in Brooklyn, New York. At one point Galasso claimed in her catalogs and shipping labels to be the "World's Largest Hobby Card Dealer". Galasso printed some cards in partnerships with Topps and The Card Memorabilia Associates, Ltd. (TCMA), and eventually printed some independent card sets as well.
The company continued in the sports card business until at least the late 1990s. Renata Galasso Inc. is currently listed online as a retail mail-order house.