Replication protein A1

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Replication protein A1, 70kDa
Protein RPA1 PDB 1ewi.png
PDB rendering based on 1ewi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RPA1 ; HSSB; MST075; REPA1; RF-A; RP-A; RPA70
External IDs OMIM179835 MGI1915525 HomoloGene2208 ChEMBL: 1764940 GeneCards: RPA1 Gene
Species Human Mouse
Entrez 6117 68275
Ensembl ENSG00000132383 ENSMUSG00000000751
UniProt P27694 Q8VEE4
RefSeq (mRNA) NM_002945 NM_001164223
RefSeq (protein) NP_002936 NP_001157695
Location (UCSC) Chr 17:
1.73 – 1.8 Mb
Chr 11:
75.3 – 75.35 Mb
PubMed search [1] [2]

Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the RPA1 gene.[1]


Replication protein A1 has been shown to interact with:


  1. ^ Umbricht C, Erdile L, Jabs E, Kelly T (April 1993). "Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A". J Biol Chem 268 (9): 6131–8. PMID 8454588. 
  2. ^ Wong J, Ionescu D, Ingles C (January 2003). "Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2". Oncogene 22 (1): 28–33. doi:10.1038/sj.onc.1206071. PMID 12527904. 
  3. ^ Brosh R, Li J, Kenny M, Karow J, Cooper M, Kureekattil R et al. (August 2000). "Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity". J. Biol. Chem. 275 (31): 23500–8. doi:10.1074/jbc.M001557200. PMID 10825162. 
  4. ^ Opresko P, von Kobbe C, Laine J, Harrigan J, Hickson I, Bohr V (October 2002). "Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases". J. Biol. Chem. 277 (43): 41110–9. doi:10.1074/jbc.M205396200. PMID 12181313. 
  5. ^ Moens P, Kolas N, Tarsounas M, Marcon E, Cohen P, Spyropoulos B (April 2002). "The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination". J. Cell. Sci. 115 (Pt 8): 1611–22. PMID 11950880. 
  6. ^ a b c d e f Kneissl M, Pütter V, Szalay A, Grummt F (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. PMID 12614612. 
  7. ^ Parker A, Gu Y, Mahoney W, Lee S, Singh K, Lu A (February 2001). "Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair". J. Biol. Chem. 276 (8): 5547–55. doi:10.1074/jbc.M008463200. PMID 11092888. 
  8. ^ Romanova L, Willers H, Blagosklonny M, Powell S (Dec 2004). "The interaction of p53 with replication protein A mediates suppression of homologous recombination". Oncogene 23 (56): 9025–33. doi:10.1038/sj.onc.1207982. PMID 15489903. 
  9. ^ Riva F, Zuco V, Vink A, Supino R, Prosperi E (Dec 2001). "UV-induced DNA incision and proliferating cell nuclear antigen recruitment to repair sites occur independently of p53-replication protein A interaction in p53 wild type and mutant ovarian carcinoma cells". Carcinogenesis 22 (12): 1971–8. PMID 11751427. 
  10. ^ Shao R, Cao C, Zhang H, Kohn K, Wold M, Pommier Y (March 1999). "Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes". EMBO J. 18 (5): 1397–406. doi:10.1093/emboj/18.5.1397. PMC 1171229. PMID 10064605. 
  11. ^ a b Bochkareva E, Korolev S, Lees-Miller S, Bochkarev A (April 2002). "Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA". EMBO J. 21 (7): 1855–63. doi:10.1093/emboj/21.7.1855. PMC 125950. PMID 11927569. 
  12. ^ Bochkareva E, Frappier L, Edwards A, Bochkarev A (February 1998). "The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain". J. Biol. Chem. 273 (7): 3932–6. PMID 9461578. 
  13. ^ Unsal-Kaçmaz K, Chastain P, Qu P, Minoo P, Cordeiro-Stone M, Sancar A et al. (April 2007). "The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement". Mol. Cell. Biol. 27 (8): 3131–42. doi:10.1128/MCB.02190-06. PMC 1899931. PMID 17296725. 
  14. ^ Yoo E, Kim B, Lee S, Cho C, Chung J, Lee C (August 2005). "53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damage". Oncogene 24 (35): 5423–30. doi:10.1038/sj.onc.1208710. PMID 15856006. 
  15. ^ Li L, Lu X, Peterson C, Legerski R (October 1995). "An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair". Mol. Cell. Biol. 15 (10): 5396–402. PMC 230789. PMID 7565690. 

Further reading[edit]