Replicative transposition is a mechanism of transposition in molecular biology, proposed by James A. Shapiro in 1979, in which the transposable element is duplicated during the reaction, so that the transposing entity is a copy of the original element. In this mechanism, the donor and receptor DNA sequences form a characteristic intermediate "theta" configuration, sometimes called a "Shapiro intermediate". Replicative transposition is characteristic to retrotransposons and occurs from time to time in class II transposons.
- Shapiro, J. A. (1979), "Molecular model for the transposition and replication of bacteriophage Mu and other transposable elements", Proceedings of the National Academy of Sciences of the United States of America 76 (4): 1933–1937, doi:10.1073/pnas.76.4.1933, PMC 383507, PMID 287033.
- Bushman, Frederic (2002), Lateral DNA transfer: mechanisms and consequences, CSHL Press, p. 46, ISBN 978-0-87969-621-4.
- Chaconas, George; Harshey, Rasika M. (2002), "Transposition of phage Mu DNA", in Craig, N. L.; Craigie, R.; Gellert, M. et al., Mobile DNA II, American Society for Microbiology, pp. 384–402 .