Resolvin

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Resolvin D2 (RvD2)

Resolvins are compounds that are made by the human body from the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). They are produced by the COX-2 pathway especially in the presence of aspirin. Experimental evidence indicates that resolvins reduce cellular inflammation by inhibiting the production and transportation of inflammatory cells and chemicals to the sites of inflammation. [1]

Other biological actions have been reported, with therapeutical potential such as a reduction in inflammatory pain. [2]

The EPA-derived resolvins are nonclassic eicosanoids.

External links[edit]

  1. ^ Serhan CN, Hong S, Gronert K, et al.abg (2002). "Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals". J. Exp. Med. 196 (8): 1025–37. doi:10.1084/jem.20020760. PMC 2194036. PMID 12391014. Retrieved 2007-11-02. 
  2. ^ Xu ZZ, Zhang L, Liu T, et al. (2010). "Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions.". Nat. Medicine 16 (5): 592–7, 1p following 597. doi:10.1038/nm.2123. PMC 2866054. PMID 20383154.