Retinal dehydrogenase

From Wikipedia, the free encyclopedia
Jump to: navigation, search
retinal dehydrogenase
Identifiers
EC number 1.2.1.36
CAS number 37250-99-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a retinal dehydrogenase (EC 1.2.1.36) is an enzyme that catalyzes the chemical reaction

retinal + NAD+ + H2O \rightleftharpoons retinoic acid + NADH + H+

The 3 substrates of this enzyme are retinal, NAD+, and H2O, whereas its 3 products are retinoic acid, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is retinal:NAD+ oxidoreductase. This enzyme is also called cytosolic retinal dehydrogenase. This enzyme participates in retinol metabolism. It has 2 cofactors: FAD, and Metal.

References[edit]

  • Moffa DJ, Lotspeich FJ, Krause RF (1970). "Preparation and properties of retinal-oxidizing enzyme from rat intestinal mucosa". J. Biol. Chem. 245 (2): 439–47. PMID 4312676.