This gene encodes a homeobox-containing transcription factor that functions in eye development. The gene is expressed early in the eye primordia, and is required for retinal cell fate determination and also regulates stem cell proliferation.
Rax (Retina and Anterior Neural Fold Homeobox) is a gene in the OAR (Otx, Arx,& Rax) subgroup of the paired-like homeodomain family of transcription factors. Discovered in 1997, the Rax gene is known to contribute to the development of the retina, hypothalamus, pineal gland and pituitary gland.
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^Voronina VA, Kozhemyakina EA, O'Kernick CM, Kahn ND, Wenger SL, Linberg JV, Schneider AS, Mathers PH (February 2004). "Mutations in the human RAX homeobox gene in a patient with anophthalmia and sclerocornea". Hum. Mol. Genet.13 (3): 315–22. doi:10.1093/hmg/ddh025. PMID14662654.