Retinoblastoma-like protein 2

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Retinoblastoma-like 2
Symbols RBL2 ; P130; Rb2
External IDs OMIM180203 MGI105085 HomoloGene4098 GeneCards: RBL2 Gene
RNA expression pattern
PBB GE RBL2 212331 at tn.png
PBB GE RBL2 212332 at tn.png
More reference expression data
Species Human Mouse
Entrez 5934 19651
Ensembl ENSG00000103479 ENSMUSG00000031666
UniProt Q08999 Q64700
RefSeq (mRNA) NM_005611 NM_001282000
RefSeq (protein) NP_005602 NP_001268929
Location (UCSC) Chr 16:
53.47 – 53.53 Mb
Chr 8:
91.07 – 91.12 Mb
PubMed search [1] [2]

Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene.[1][2]


Retinoblastoma-like protein 2 has been shown to interact with HDAC1,[3][4] C-Raf,[5] RBBP8,[6][7] Cyclin E1,[8][9] Prohibitin,[10] Cyclin-dependent kinase 2,[8][11] BRF1[12] and BRCA1.[13]

See also[edit]

Further reading[edit]


  1. ^ Mayol X, Grana X, Baldi A, Sang N, Hu Q, Giordano A (September 1993). "Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain". Oncogene 8 (9): 2561–6. PMID 8361765. 
  2. ^ Baldi A, Boccia V, Claudio PP, De Luca A, Giordano A (July 1996). "Genomic structure of the human retinoblastoma-related Rb2/p130 gene". Proc Natl Acad Sci U S A 93 (10): 4629–32. doi:10.1073/pnas.93.10.4629. PMC 39329. PMID 8643454. 
  3. ^ Ferreira, R; Magnaghi-Jaulin L; Robin P; Harel-Bellan A; Trouche D (September 1998). "The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (18): 10493–8. doi:10.1073/pnas.95.18.10493. ISSN 0027-8424. PMC 27922. PMID 9724731. 
  4. ^ Bouzahzah, B; Fu M; Iavarone A; Factor V M; Thorgeirsson S S; Pestell R G (August 2000). "Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo". Cancer Res. (UNITED STATES) 60 (16): 4531–7. ISSN 0008-5472. PMID 10969803. 
  5. ^ Wang, S; Ghosh R N; Chellappan S P (Dec 1998). "Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation". Mol. Cell. Biol. (UNITED STATES) 18 (12): 7487–98. ISSN 0270-7306. PMC 109329. PMID 9819434. 
  6. ^ Meloni, A R; Smith E J; Nevins J R (August 1999). "A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (17): 9574–9. doi:10.1073/pnas.96.17.9574. ISSN 0027-8424. PMC 22250. PMID 10449734. 
  7. ^ Fusco, C; Reymond A; Zervos A S (August 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Genomics (UNITED STATES) 51 (3): 351–8. doi:10.1006/geno.1998.5368. ISSN 0888-7543. PMID 9721205. 
  8. ^ a b Shanahan, F; Seghezzi W; Parry D; Mahony D; Lees E (February 1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest". Mol. Cell. Biol. (UNITED STATES) 19 (2): 1460–9. ISSN 0270-7306. PMC 116074. PMID 9891079. 
  9. ^ Li, Y; Graham C; Lacy S; Duncan A M; Whyte P (Dec 1993). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E". Genes Dev. (UNITED STATES) 7 (12A): 2366–77. doi:10.1101/gad.7.12a.2366. ISSN 0890-9369. PMID 8253383. 
  10. ^ Wang, S; Nath N; Adlam M; Chellappan S (June 1999). "Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function". Oncogene (ENGLAND) 18 (23): 3501–10. doi:10.1038/sj.onc.1202684. ISSN 0950-9232. PMID 10376528. 
  11. ^ Lacy, S; Whyte P (May 1997). "Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes". Oncogene (ENGLAND) 14 (20): 2395–406. doi:10.1038/sj.onc.1201085. ISSN 0950-9232. PMID 9188854. 
  12. ^ Sutcliffe, J E; Cairns C A; McLees A; Allison S J; Tosh K; White R J (June 1999). "RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130". Mol. Cell. Biol. (UNITED STATES) 19 (6): 4255–61. ISSN 0270-7306. PMC 104385. PMID 10330166. 
  13. ^ Fan, S; Yuan R; Ma Y X; Xiong J; Meng Q; Erdos M; Zhao J N; Goldberg I D; Pestell R G; Rosen E M (August 2001). "Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding". Oncogene (England) 20 (35): 4827–41. doi:10.1038/sj.onc.1204666. ISSN 0950-9232. PMID 11521194. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.