Retinoid X receptor beta

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Retinoid X receptor, beta
Protein RXRB PDB 1by4.png
PDB rendering based on 1by4.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RXRB ; DAUDI6; H-2RIIBP; NR2B2; RCoR-1
External IDs OMIM180246 MGI98215 HomoloGene7923 IUPHAR: NR2B2 ChEMBL: 1870 GeneCards: RXRB Gene
RNA expression pattern
PBB GE RXRB 209148 at tn.png
PBB GE RXRB 215099 s at tn.png
PBB GE RXRB 215098 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6257 20182
Ensembl ENSG00000204231 ENSMUSG00000039656
UniProt P28702 P28704
RefSeq (mRNA) NM_001270401 NM_001205214
RefSeq (protein) NP_001257330 NP_001192143
Location (UCSC) Chr 6:
33.16 – 33.17 Mb
Chr 17:
34.03 – 34.04 Mb
PubMed search [1] [2]

Retinoid X receptor beta (RXR-beta), also known as NR2B2 (nuclear receptor subfamily 2, group B, member 2) is a nuclear receptor that in humans is encoded by the RXRB gene.[1][2]

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. The gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.[2]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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VitaminDSynthesis_WP1531 Go to article Go to article Go to article Go to article go to article Go to article Go to article Go to article go to article go to article go to article go to article Go to article Go to article go to article Go to article go to article go to article go to article Go to article go to article
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Vitamin D Synthesis Pathway edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "VitaminDSynthesis_WP1531". 

See also[edit]

References[edit]

  1. ^ Fitzgibbon J, Gillett GT, Woodward KJ, Boyle JM, Wolfe J, Povey S (July 1993). "Mapping of RXRB to human chromosome 6p21.3". Ann. Hum. Genet. 57 (Pt 3): 203–9. doi:10.1111/j.1469-1809.1993.tb01596.x. PMID 8257090. 
  2. ^ a b "Entrez Gene: RXRB retinoid X receptor, beta". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.