Retinol binding protein 4

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Retinol binding protein 4, plasma
Retinol binding protein 1RBP.png
Human serum retinol binding protein. From PDB 1RBP.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RBP4 ; RDCCAS
External IDs OMIM180250 MGI97879 HomoloGene4908 IUPHAR: 2549 ChEMBL: 3100 GeneCards: RBP4 Gene
RNA expression pattern
PBB GE RBP4 219140 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5950 19662
Ensembl ENSG00000138207 ENSMUSG00000024990
UniProt P02753 Q00724
RefSeq (mRNA) NM_006744 NM_001159487
RefSeq (protein) NP_006735 NP_001152959
Location (UCSC) Chr 10:
95.35 – 95.36 Mb
Chr 19:
38.12 – 38.13 Mb
PubMed search [1] [2]

Retinol binding protein 4, plasma, also known as RBP4, is a protein[1] that in humans is encoded by the RBP4 gene.[2][3]


This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells.[3]

Clinical significance[edit]

Retinol-binding protein 4 has recently been described as an adipokine that contributes to insulin resistance in the AG4KO mouse model.[4] It is secreted by adipocytes, and can act as a signal to other cells, when there is a decrease in plasma glucose concentration.[5]

See also[edit]


  1. ^ Rask L, Anundi H, Fohlman J, Peterson PA (1987). "The complete amino acid sequence of human serum retinol-binding protein". Upsala Journal of Medical Sciences 92 (2): 115–46. doi:10.3109/03009738709178685. PMID 2444024. 
  2. ^ Rocchi M, Covone A, Romeo G, Faraonio R, Colantuoni V (March 1989). "Regional mapping of RBP4 to 10q23----q24 and RBP1 to 3q21----q22 in man". Somatic Cell and Molecular Genetics 15 (2): 185–90. doi:10.1007/BF01535081. PMID 2928844. 
  3. ^ a b "Entrez Gene: RBP4 retinol binding protein 4, plasma". 
  4. ^ Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB (2005). "Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes". Nature 436 (7049): 356–62. doi:10.1038/nature03711. PMID 16034410. 
  5. ^ Herman MA, Kahn BB (2006). "Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony". J. Clin. Invest. 116 (7): 1767–75. doi:10.1172/JCI29027. PMC 1483149. PMID 16823474. 

Further reading[edit]

External links[edit]