Retrograde signaling

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Retrograde signaling in biology is a process whereby function of one part of a cell is controlled by feedback from another part of the cell, or where one cell sends reciprocal messages back to another cell that regulates it.

In cell biology, retrograde signaling occurs between different subcellular organelles. A typical example in plants is retrograde signaling from the plastid to control nuclear gene expression.[1]

In neuroscience, retrograde signaling (or retrograde neurotransmission) refers more specifically to the process by which a retrograde messenger, such as anandamide or nitric oxide, is released by a postsynaptic dendrite or cell body, and travels "backwards" across a chemical synapse to bind to the axon terminal of a presynaptic neuron.[2]

In cell biology[edit]

Retrograde signalling can go from plastids to the nucleus in plants,[1][3] or from mitochondria to the nucleus in yeast.[4]

In neuroscience[edit]

The primary purpose of retrograde neurotransmission is regulation of chemical neurotransmission.[2] For this reason, retrograde neurotransmission allows neural circuits to create feedback loops. In the sense that retrograde neurotransmission mainly serves to regulate typical, anterograde neurotransmission, rather than to actually distribute any information, it is similar to electrical neurotransmission.

In contrast to conventional (anterograde) neurotransmitters, retrograde neurotransmitters are synthesized in the postsynaptic neuron, and bind to receptors on the axon terminal of the presynaptic neuron.

Endocannabinoids like anandamide are known to act as retrograde messengers,[5][6][7] as is nitric oxide.[8][9]

Retrograde signaling may also play a role in long-term potentiation, a proposed mechanism of learning and memory, although this is controversial.

Formal definition of a retrograde neurotransmitter[edit]

In 2009, Regehr et al. proposed criteria for defining retrograde neurotransmitters. According to their work, a signaling molecule can be considered a retrograde neurotransmitter if it satisfies all of the following criteria:[2]

  • The appropriate machinery for synthesizing and releasing the retrograde messenger must be located in the postsynaptic neuron
  • Disrupting the synthesis and/or release of the messenger from the postsynaptic neuron must prevent retrograde signaling
  • The appropriate targets for the retrograde messenger must be located in the presynaptic bouton
  • Disrupting the targets for the retrograde messenger in the presynaptic boutons must eliminate retrograde signaling
  • Exposing the presynaptic bouton to the messenger should mimic retrograde signaling provided the presence of the retrograde messenger is sufficient for retrograde signaling to occur
  • In cases where the retrograde messenger is not sufficient, pairing the other factor(s) with the retrograde signal should mimic the phenomenon

Types of retrograde neurotransmitters[edit]

The most prevalent endogenous retrograde neurotransmitters are nitric oxide and various cannabinoids.

Retrograde signaling in long-term potentiation[edit]

As it pertains to long-term potentiation (LTP), retrograde signaling is a hypothesis describing how events underlying LTP may begin in the postsynaptic neuron but be propagated to the presynaptic neuron, even though normal communication across a chemical synapse occurs in a presynaptic to postsynaptic direction. It is used most commonly by those who argue that presynaptic neurons contribute significantly to the expression of LTP.

Background[edit]

Long-term potentiation is the persistent increase in the strength of a chemical synapse that lasts from hours to days. It is thought to occur via two temporally separated events, with induction occurring first, followed by expression. Most LTP investigators agree that induction is entirely postsynaptic, whereas there is disagreement as to whether expression is principally a presynaptic or postsynaptic event. Some researchers believe that both presynaptic and postsynaptic mechanisms play a role in LTP expression.

Were LTP entirely induced and expressed postsynaptically, there would be no need for the postsynaptic cell to communicate with the presynaptic cell following LTP induction. However, postsynaptic induction combined with presynaptic expression requires that, following induction, the postsynaptic cell must communicate with the presynaptic cell. Because normal synaptic transmission occurs in a presynaptic to postsynaptic direction, postsynaptic to presynaptic communication is considered a form of retrograde transmission.

Mechanism[edit]

The retrograde signaling hypothesis proposes that during the early stages of LTP expression, the postsynaptic cell "sends a message" to the presynaptic cell to notify it that an LTP-inducing stimulus has been received postsynaptically. The general hypothesis of retrograde signaling does not propose a precise mechanism by which this message is sent and received. One mechanism may be that the postsynaptic cell synthesizes and releases a retrograde messenger upon receipt of LTP-inducing stimulation.[10][11] Another is that it releases a preformed retrograde messenger upon such activation. Yet another mechanism is that synapse-spanning proteins may be altered by LTP-inducing stimuli in the postsynaptic cell, and that changes in conformation of these proteins propagates this information across the synapse and to the presynaptic cell.[12]

Identity of the messenger[edit]

Of these mechanisms, the retrograde messenger hypothesis has received the most attention. Among proponents of the model, there is disagreement over the identity of the retrograde messenger. A flurry of work in the early 1990s to demonstrate the existence of a retrograde messenger and to determine its identity generated a list of candidates including carbon monoxide,[13] platelet-activating factor,[14][15] arachidonic acid,[16] and nitric oxide. Nitric oxide has received a great deal of attention in the past, but has recently been superseded by adhesion proteins that span the synaptic cleft to join the presynaptic and postsynaptic cells.[12] The endocannabinoids anandamide and/or 2-AG, acting through G-protein coupled cannabinoid receptors, may play an important role in retrograde signaling in LTP.[5][6]

References[edit]

  1. ^ a b Lagarias JC, Duanmu D; Casero D, Dent RM, Gallaher S, Yang W, Rockwell NC, Martin SS, Pellegrini M, Niyogi KK, Merchant SS, Grossman AR (26 Feb 2013). "Retrograde bilin signaling enables Chlamydomonas greening and phototrophic survival.". Proceedings of the National Academy of Sciences of the United States of America 110 (9): 3621–3626. doi:10.1073/pnas.1222375110. PMC 3587268. PMID 23345435. 
  2. ^ a b c Regehr, Wade G.; Carey, Megan R.; Best, Aaron R. (30 July 2009). "Activity-Dependent Regulation of Synapses by Retrograde Messengers". Neuron 63 (2): 154–170. doi:10.1016/j.neuron.2009.06.021. PMC 3251517. PMID 19640475. 
  3. ^ Nott, Ajit; Jung, Hou-Sung; Koussevitzky, Shai; Chory, Joanne (June 2006). "Plastid-to-nucleus retrograde signaling". Annual Review of Plant Biology 57: 739–759. doi:10.1146/annurev.arplant.57.032905.105310. Retrieved May 5, 2014. 
  4. ^ Liu, Zhengchang; Butow, Ronald A. (December 2006). "Mitochondrial retrograde signaling". Annual Review of Genetics 40: 159–185. doi:10.1146/annurev.genet.40.110405.090613. Retrieved May 5, 2014. 
  5. ^ a b Alger BE (2002). "Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids". Prog. Neurobiol. 68 (4): 247–86. doi:10.1016/S0301-0082(02)00080-1. PMID 12498988. 
  6. ^ a b Wilson RI, Nicoll RA (2001). "Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses". Nature 410 (6828): 588–92. doi:10.1038/35069076. PMID 11279497. 
  7. ^ Kreitzer, A.; Regehr, W. G. (2002). "Retrograde signaling by endocannabinoids". Current Opinion in Neurobiology 12 (3): 324–330. doi:10.1016/S0959-4388(02)00328-8. PMID 12049940.  edit
  8. ^ O'Dell, TJ; Hawkins, RD; Kandel, ER; Arancio, O (Dec 15, 1991). "Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.". Proceedings of the National Academy of Sciences of the United States of America 88 (24): 11285–9. doi:10.1073/pnas.88.24.11285. PMID 1684863. 
  9. ^ Malen, PL; Chapman, PF (Apr 1, 1997). "Nitric oxide facilitates long-term potentiation, but not long-term depression.". The Journal of neuroscience : the official journal of the Society for Neuroscience 17 (7): 2645–51. PMID 9065524. 
  10. ^ Garthwaite, J (Feb 1991). "Glutamate, nitric oxide and cell-cell signalling in the nervous system.". Trends in neurosciences 14 (2): 60–7. doi:10.1016/0166-2236(91)90022-M. PMID 1708538. 
  11. ^ Lei, S; Jackson, MF; Jia, Z; Roder, J; Bai, D; Orser, BA; MacDonald, JF (Jun 2000). "Cyclic GMP-dependent feedback inhibition of AMPA receptors is independent of PKG.". Nature neuroscience 3 (6): 559–65. doi:10.1038/75729. PMID 10816311. 
  12. ^ a b Malenka R, Bear M (2004). "LTP and LTD: an embarrassment of riches". Neuron 44 (1): 5–21. doi:10.1016/j.neuron.2004.09.012. PMID 15450156. 
  13. ^ Alkadhi K, Al-Hijailan R, Malik K, Hogan Y (2001). "Retrograde carbon monoxide is required for induction of long-term potentiation in rat superior cervical ganglion". J Neurosci 21 (10): 3515–20. PMID 11331380. 
  14. ^ Kato K, Zorumski C (1996). "Platelet-activating factor as a potential retrograde messenger". J Lipid Mediat Cell Signal 14 (1–3): 341–8. doi:10.1016/0929-7855(96)00543-3. PMID 8906580. 
  15. ^ Kato K, Clark G, Bazan N, Zorumski C (1994). "Platelet-activating factor as a potential retrograde messenger in CA1 hippocampal long-term potentiation". Nature 367 (6459): 175–9. doi:10.1038/367175a0. PMID 8114914. 
  16. ^ Carta, Mario (2014). "Membrane Lipids Tune Synaptic Transmission by Direct Modulation of Presynaptic Potassium Channels". Neuron. doi:10.1016/j.neuron.2013.12.028.