Rezh (Russian: Реж) is a river in Sverdlovsk Oblast, Russia. It is a tributary of the Nitsa River (in the Ob's drainage basin). It is 219 km long, with a drainage basin of 4,350 km².
The Rezh has its sources in the central Ural Mountains, and flows towards the northeast towards its confluence with the Nitsa. The largest town by the river is Rezh.
Coordinates: 57°54′42″N 62°18′39″E / 57.91167°N 62.31083°E / 57.91167; 62.31083