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Ras homolog family member D
Protein RHOD PDB 2j1l.png
PDB rendering based on 2j1l.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RHOD ; ARHD; RHOHP1; RHOM; Rho
External IDs OMIM605781 MGI108446 HomoloGene22409 GeneCards: RHOD Gene
RNA expression pattern
PBB GE RHOD 31846 at tn.png
PBB GE RHOD 209885 at tn.png
More reference expression data
Species Human Mouse
Entrez 29984 11854
Ensembl ENSG00000173156 ENSMUSG00000041845
UniProt O00212 P97348
RefSeq (mRNA) NM_001300886 NM_007485
RefSeq (protein) NP_001287815 NP_031511
Location (UCSC) Chr 11:
66.82 – 66.84 Mb
Chr 19:
4.43 – 4.44 Mb
PubMed search [1] [2]

RhoD (Ras homolog gene family, member D) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.[1] It is encoded by the gene RHOD.[2]

It binds GTP and is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton.[2]


RhoD has been shown to interact with CNKSR1[3] and DIAPH2.[4]


  1. ^ Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. ISSN 0962-8924. PMID 16949823. 
  2. ^ a b "Entrez Gene: RHOD ras homolog gene family, member D". 
  3. ^ Jaffe, Aron B; Aspenström Pontus; Hall Alan (Feb 2004). "Human CNK1 Acts as a Scaffold Protein, Linking Rho and Ras Signal Transduction Pathways". Mol. Cell. Biol. (United States) 24 (4): 1736–46. doi:10.1128/MCB.24.4.1736-1746.2004. ISSN 0270-7306. PMC 344169. PMID 14749388. 
  4. ^ Gasman, Stéphane; Kalaidzidis Yannis; Zerial Marino (Mar 2003). "RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase". Nat. Cell Biol. (England) 5 (3): 195–204. doi:10.1038/ncb935. ISSN 1465-7392. PMID 12577064. 

Further reading[edit]