RhoGEF domain

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RhoGEF domain
PDB 1dbh EBI.jpg
Structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein.[1]
Identifiers
Symbol RhoGEF
Pfam PF00621
InterPro IPR000219
SMART RhoGEF
SCOP 1dbh
SUPERFAMILY 1dbh
OPM protein 1xd4

RhoGEF domain is a structural domain of guanine nucleotide exchange factors for Rho/Rac/Cdc42-like GTPases. It is also called "Dbl-homologous" (DH) domain.

Subfamilies[edit]

Human proteins containing this domain[edit]

ABR; AKAP13; ARHGEF1; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF15; ARHGEF16; ARHGEF17; ARHGEF18; ARHGEF19; ARHGEF2; ARHGEF3; ARHGEF4; ARHGEF5; ARHGEF6; ARHGEF7; ARHGEF9; ASEF2; BCR; C9orf100; DEPDC2; DNMBP; ECT2; FARP1; FARP2; FGD1; FGD2; FGD3; FGD4; FGD5; FGD6; GEFT; ITSN1; ITSN2; KALRN; LFDH; MCF2; MCF2L; MCF2L2; NET1; NGEF; OBSCN; PLEKHG1; PLEKHG2; PLEKHG3; PLEKHG4; PLEKHG5; PLEKHG6; PREX1; RASGRF1; SGEF; SOS1; SOS2; SPATA13; TIAM1; TIAM2; TRIO; VAV1; VAV2; VAV3;

Notes[edit]

  1. ^ Soisson, S.; Nimnual, A.; Uy, M.; Bar-Sagi, D.; Kuriyan, J. (1998). "Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein". Cell 95 (2): 259–268. doi:10.1016/S0092-8674(00)81756-0. PMID 9790532.  edit

References[edit]

  • Cerione, R. A.; Zheng, Y. (1996). "The Dbl family of oncogenes". Current opinion in cell biology 8 (2): 216–222. doi:10.1016/s0955-0674(96)80068-8. PMID 8791419.  edit
  • Hart, M. J.; Eva, A.; Evans, T.; Aaronson, S. A.; Cerione, R. A. (1991). "Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product". Nature 354 (6351): 311–314. doi:10.1038/354311a0. PMID 1956381.  edit
  • Tan, E. C.; Leung, T.; Manser, E.; Lim, L. (1993). "The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins". The Journal of biological chemistry 268 (36): 27291–27298. PMID 8262969.  edit
  • Soisson, S.; Nimnual, A.; Uy, M.; Bar-Sagi, D.; Kuriyan, J. (1998). "Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein". Cell 95 (2): 259–268. doi:10.1016/S0092-8674(00)81756-0. PMID 9790532.  edit