RhoH

Ras homolog gene family, member H
Identifiers
Symbols	RHOH; ARHH; TTF
External IDs	OMIM: 602037 MGI: 1921984 HomoloGene: 3180 GeneCards: RHOH Gene
Gene Ontology Molecular function • nucleotide binding • GTPase inhibitor activity • protein binding • GTP binding • Rho GTPase binding • kinase inhibitor activity Cellular component • intracellular • cytoplasm • mitochondrion • cytosol • plasma membrane Biological process • regulation of transcription, DNA-dependent • small GTPase mediated signal transduction • T cell differentiation • negative regulation of phosphorylation • negative regulation of I-kappaB kinase/NF-kappaB cascade • regulation of small GTPase mediated signal transduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	399	74734
Ensembl	ENSG00000168421	ENSMUSG00000029204
UniProt	Q15669	Q3TEI3
RefSeq (mRNA)	NM_004310	NM_001081105.1
RefSeq (protein)	NP_004301	NP_001074574.1
Location (UCSC)	Chr 4: 40.19 – 40.25 Mb	Chr 5: 66.25 – 66.29 Mb
PubMed search	[1]	[2]

RhoH (Ras homolog gene family, member H) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. It is encoded by the gene RHOH.

Gene

Expression of a chimeric transcript of LAZ3 and this gene has been reported as a result of the translocation t(3;4) in non-Hodgkin's lymphomas. Unlike most other small G proteins which are expressed ubiquitously, this gene is transcribed only in hemopoietic cells.

Interactions

RhoH has been shown to interact with ARHGDIA.

Further reading

• Dallery E, Galiègue-Zouitina S, Collyn-d'Hooghe M et al (1995). "TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation". Oncogene 10 (11): 2171–8. PMID 7784061. 
• Dallery-Prudhomme E, Roumier C, Denis C et al (1997). "Genomic structure and assignment of the RhoH/TTF small GTPase gene (ARHH) to 4p13 by in situ hybridization". Genomics 43 (1): 89–94. doi:10.1006/geno.1997.4788. PMID 9226377. 
• Yousefi S, Cooper PR, Mueck B et al (2000). "cDNA representational difference analysis of human neutrophils stimulated by GM-CSF". Biochem. Biophys. Res. Commun. 277 (2): 401–9. doi:10.1006/bbrc.2000.3678. PMID 11032736. 
• Fauré J, Dagher MC (2001). "Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI)". Biochimie 83 (5): 409–14. doi:10.1016/S0300-9084(01)01263-9. PMID 11368848. 
• Li X, Bu X, Lu B et al (2002). "The Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function". Mol. Cell. Biol. 22 (4): 1158–71. doi:10.1128/MCB.22.4.1158-1171.2002. PMC 134637. PMID 11809807. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=134637. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gerhard DS, Wagner L, Feingold EA et al (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Lahousse S, Smorowski AL, Denis C et al (2005). "Structural features of hematopoiesis-specific RhoH/ARHH gene: high diversity of 5'-UTR in different hematopoietic lineages suggests a complex post-transcriptional regulation". Gene 343 (1): 55–68. doi:10.1016/j.gene.2004.08.022. PMID 15563831. 
• Lopez-Ilasaca MA, Bernabe-Ortiz JC, Na SY et al (2005). "Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells". FEBS Lett. 579 (3): 648–54. doi:10.1016/j.febslet.2004.12.039. PMID 15670823. 
• Barrios-Rodiles M, Brown KR, Ozdamar B et al (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153. 
• Rual JF, Venkatesan K, Hao T et al (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Kimura K, Wakamatsu A, Suzuki Y et al (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129. 
• Reiniger L, Bödör C, Bognár A et al (2006). "Richter's and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation-induced cytidine deaminase and aberrant somatic hypermutation". Leukemia 20 (6): 1089–95. doi:10.1038/sj.leu.2404183. PMID 16541139. 
• Hiraga J, Katsumi A, Iwasaki T et al (2007). "Prognostic analysis of aberrant somatic hypermutation of RhoH gene in diffuse large B cell lymphoma". Leukemia 21 (8): 1846–7. doi:10.1038/sj.leu.2404717. PMID 17443219. 
• Traverse-Glehen A, Verney A, Baseggio L et al (2007). "Analysis of BCL-6, CD95, PIM1, RHO/TTF and PAX5 mutations in splenic and nodal marginal zone B-cell lymphomas suggests a particular B-cell origin". Leukemia 21 (8): 1821–4. doi:10.1038/sj.leu.2404706. PMID 17476282.