RhoH

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Ras homolog family member H
Identifiers
Symbols RHOH ; ARHH; TTF
External IDs OMIM602037 MGI1921984 HomoloGene3180 GeneCards: RHOH Gene
RNA expression pattern
PBB GE RHOH 204951 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 399 74734
Ensembl ENSG00000168421 ENSMUSG00000029204
UniProt Q15669 Q9D3G9
RefSeq (mRNA) NM_001278359 NM_001081105
RefSeq (protein) NP_001265288 NP_001074574
Location (UCSC) Chr 4:
40.19 – 40.25 Mb
Chr 5:
65.86 – 65.9 Mb
PubMed search [1] [2]

RhoH (Ras homolog gene family, member H) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.[1] It is encoded by the gene RHOH.[2]

Gene[edit]

Expression of a chimeric transcript of LAZ3 and this gene has been reported as a result of the translocation t(3;4) in non-Hodgkin's lymphomas. Unlike most other small G proteins which are expressed ubiquitously, this gene is transcribed only in hemopoietic cells.[2]

Interactions[edit]

RhoH has been shown to interact with ARHGDIA.[3][4]

References[edit]

  1. ^ Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. ISSN 0962-8924. PMID 16949823. 
  2. ^ a b "Entrez Gene: RHOH ras homolog gene family, member H". 
  3. ^ Li, Xiaoyu; Bu Xia; Lu Binfeng; Avraham Hava; Flavell Richard A; Lim Bing (February 2002). "The Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function". Mol. Cell. Biol. (United States) 22 (4): 1158–71. doi:10.1128/MCB.22.4.1158-1171.2002. ISSN 0270-7306. PMC 134637. PMID 11809807. 
  4. ^ Fauré, J; Dagher M C (May 2001). "Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI)". Biochimie (France) 83 (5): 409–14. doi:10.1016/S0300-9084(01)01263-9. ISSN 0300-9084. PMID 11368848. 

Further reading[edit]