Rhodopsin kinase

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G protein-coupled receptor kinase 1
Identifiers
Symbol GRK1
Alt. symbols RHOK
Entrez 6011
HUGO 10013
OMIM 180381
RefSeq NM_002929
UniProt Q15835
Other data
EC number 2.7.11.14
Locus Chr. 13 q34

Rhodopsin kinase (EC 2.7.11.14, cone opsin kinase, G-protein-coupled receptor kinase 1, GPCR kinase 1, GRK1, GRK7, opsin kinase, opsin kinase (phosphorylating), rhodopsin kinase (phosphorylating), RK, STK14) is a serine/threonine-specific protein kinase involved in phototransduction.[1][2][3][4][5][6][7][8] This enzyme catalyses the following chemical reaction

ATP + rhodopsin \rightleftharpoons ADP + phosphorhodopsin

Mutations in rhodopsin kinase are associated with a form of night blindness called Oguchi disease.[9]

See also[edit]

References[edit]

  1. ^ Benovic, J.L., Mayor, F., Jr., Somers, R.L., Caron, M.G. and Lefkowitz, R.J. (1986). "Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase". Nature 321 (6073): 869–872. doi:10.1038/321869a0. PMID 3014340. 
  2. ^ Shichi, H. and Somers, R.L. (1978). "Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase". J. Biol. Chem. 253 (19): 7040–7046. PMID 690139. 
  3. ^ Palczewski, K., McDowell, J.H. and Hargrave, P.A. (1988). "Purification and characterization of rhodopsin kinase". J. Biol. Chem. 263 (28): 14067–14073. PMID 2844754. 
  4. ^ Weller, M., Virmaux, N. and Mandel, P. (1975). "Light-stimulated phosphorylation of rhodopsin in the retina: the presence of a protein kinase that is specific for photobleached rhodopsin". Proc. Natl. Acad. Sci. USA 72 (1): 381–385. doi:10.1073/pnas.72.1.381. PMID 164024. 
  5. ^ Cha, K., Bruel, C., Inglese, J. and Khorana, H.G. (1997). "Rhodopsin kinase: expression in baculovirus-infected insect cells, and characterization of post-translational modifications". Proc. Natl. Acad. Sci. USA 94 (20): 10577–10582. doi:10.1073/pnas.94.20.10577. PMID 9380677. 
  6. ^ Khani, S.C., Abitbol, M., Yamamoto, S., Maravic-Magovcevic, I. and Dryja, T.P. (1996). "Characterization and chromosomal localization of the gene for human rhodopsin kinase". Genomics 35 (3): 571–576. doi:10.1006/geno.1996.0399. PMID 8812493. 
  7. ^ Chen, C.K., Zhang, K., Church-Kopish, J., Huang, W., Zhang, H., Chen, Y.J., Frederick, J.M. and Baehr, W. (2001). "Characterization of human GRK7 as a potential cone opsin kinase". Mol. Vis. 7: 305–313. PMID 11754336. 
  8. ^ Willets, J.M., Challiss, R.A. and Nahorski, S.R. (2003). "Non-visual GRKs: are we seeing the whole picture?". Trends Pharmacol. Sci. 24: 626–633. doi:10.1016/j.tips.2003.10.003. PMID 14654303. 
  9. ^ Yamamoto S, Sippel KC, Berson EL, Dryja TP. (1997). "Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness.". Nat Genet USA 15 (2): 175–8. doi:10.1038/ng0297-175. PMID 9020843. 

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