Ribokinase

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ribokinase
Identifiers
EC number 2.7.1.15
CAS number 9026-84-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a ribokinase (EC 2.7.1.15) is an enzyme that catalyzes the chemical reaction

ATP + D-ribose \rightleftharpoons ADP + D-ribose 5-phosphate

Thus, the two substrates of this enzyme are ATP and D-ribose, whereas its two products are ADP and D-ribose 5-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:D-ribose 5-phosphotransferase. Other names in common use include deoxyribokinase, ribokinase (phosphorylating), and D-ribokinase. This enzyme participates in pentose phosphate pathway.

Structural studies[edit]

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1GQT, 1RK2, 1RKA, 1RKD, 1RKS, 1VM7, and 2FV7.

References[edit]

  • Agranoff BW and Brady RO (1956). "Purification and properties of calf liver ribokinase". J. Biol. Chem. 219: 221–229. 
  • GINSBURG A (1959). "A deoxyribokinase from Lactobacillus plantarum". J. Biol. Chem. 234 (3): 481–7. PMID 13641245.