Ribonuclease 4

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Ribonuclease, RNase A family, 4
Protein RNASE4 PDB 1rnf.png
PDB rendering based on 1rnf.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RNASE4 ; RNS4
External IDs OMIM601030 MGI1926217 HomoloGene10576 GeneCards: RNASE4 Gene
EC number 3.1.27.-
Orthologs
Species Human Mouse
Entrez 6038 58809
Ensembl ENSG00000181784 ENSMUSG00000021876
UniProt P34096 Q5UCA9
RefSeq (mRNA) NM_002937 NM_021472
RefSeq (protein) NP_002928 NP_067447
Location (UCSC) Chr 14:
21.15 – 21.17 Mb
Chr 14:
51.09 – 51.11 Mb
PubMed search [1] [2]

Ribonuclease 4 is an enzyme that in humans is encoded by the RNASE4 gene.[1][2]

The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region.[2]

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