Ribosomal frameshift

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A ribosomal frameshift allows alternative translation of a mRNA sequence by changing the open reading frame. It is commonly found in viruses including barley yellow dwarf virus,[1] potato leafroll virus[2] simian retrovirus-1 and coronaviruses.[3] Ribosomal frameshifting is promoted by a pseudoknot structure and slippery sequence (usually UUUAAAC).[4] It is often required for translation of putative RNA-dependent RNA polymerase.

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  1. ^ Vincent JR, Lister RM, Larkins BA (October 1991). "Nucleotide sequence analysis and genomic organization of the NY-RPV isolate of barley yellow dwarf virus". J. Gen. Virol. 72 (10): 2347–55. doi:10.1099/0022-1317-72-10-2347. PMID 1840612. 
  2. ^ Kujawa AB, Drugeon G, Hulanicka D, Haenni AL (May 1993). "Structural requirements for efficient translational frameshifting in the synthesis of the putative viral RNA-dependent RNA polymerase of potato leafroll virus". Nucleic Acids Res. 21 (9): 2165–71. doi:10.1093/nar/21.9.2165. PMC 309480. PMID 8502558. 
  3. ^ Sung D, Kang H (March 1998). "Mutational analysis of the RNA pseudoknot involved in efficient ribosomal frameshifting in simian retrovirus-1". Nucleic Acids Res. 26 (6): 1369–72. doi:10.1093/nar/26.6.1369. PMC 147434. PMID 9490779. 
  4. ^ Meulenberg JJ, Hulst MM, de Meijer EJ, et al. (January 1993). "Lelystad virus, the causative agent of porcine epidemic abortion and respiratory syndrome (PEARS), is related to LDV and EAV". Virology 192 (1): 62–72. doi:10.1006/viro.1993.1008. PMID 8517032. 

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