A ring-enhancing lesion is an abnormal radiologic sign on MRI or CT scans obtained using radiocontrast. On the image, there is an area of decreased density (see radiodensity) surrounded by a bright rim from concentration of the enhancing contrast dye. This can be a finding in numerous disease states. In the brain, it can occur with an early brain abscess as well as in Nocardia infections associated with lung cavitary lesions. In patients with HIV, the major differential is between CNS lymphoma and CNS toxoplasmosis. The ring enhancing lesions tend to be multiple in number and cerebral and basal in location in CNS toxoplasmosis.