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Rho family GTPase 1
Protein RND1 PDB 2cls.png
PDB rendering based on 2cls.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RND1 ; ARHS; RHO6; RHOS
External IDs OMIM609038 MGI2444878 HomoloGene8706 GeneCards: RND1 Gene
RNA expression pattern
PBB GE RND1 210056 at tn.png
More reference expression data
Species Human Mouse
Entrez 27289 223881
Ensembl ENSG00000172602 ENSMUSG00000054855
UniProt Q92730 Q8BLR7
RefSeq (mRNA) NM_014470 NM_172612
RefSeq (protein) NP_055285 NP_766200
Location (UCSC) Chr 12:
49.25 – 49.26 Mb
Chr 15:
98.66 – 98.68 Mb
PubMed search [1] [2]

Rnd1 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.[1] It is encoded by the gene RND1.[2]

It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM][2]


Rnd1 has been shown to interact with GRB7,[3] PLXNB1,[4] PDE6D,[5][6] ARHGAP5[7] and UBXD5.[8]


  1. ^ Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. ISSN 0962-8924. PMID 16949823. 
  2. ^ a b "Entrez Gene: RND1 Rho family GTPase 1". 
  3. ^ Vayssière, B; Zalcman G, Mahé Y, Mirey G, Ligensa T, Weidner K M, Chardin P, Camonis J (February 2000). "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family". FEBS Lett. (NETHERLANDS) 467 (1): 91–6. doi:10.1016/S0014-5793(99)01530-6. ISSN 0014-5793. PMID 10664463. 
  4. ^ Oinuma, Izumi; Katoh Hironori, Harada Amane, Negishi Manabu (July 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. (United States) 278 (28): 25671–7. doi:10.1074/jbc.M303047200. ISSN 0021-9258. PMID 12730235. 
  5. ^ Nancy, Vanessa; Callebaut Isabelle, El Marjou Ahmed, de Gunzburg Jean (April 2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". J. Biol. Chem. (United States) 277 (17): 15076–84. doi:10.1074/jbc.M109983200. ISSN 0021-9258. PMID 11786539. 
  6. ^ Hanzal-Bayer, Michael; Renault Louis, Roversi Pietro, Wittinghofer Alfred, Hillig Roman C (May 2002). "The complex of Arl2-GTP and PDEδ: from structure to function". EMBO J. (England) 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. ISSN 0261-4189. PMC 125981. PMID 11980706. 
  7. ^ Wennerberg, Krister; Forget Marie-Annick, Ellerbroek Shawn M, Arthur William T, Keith Burridge, Settleman Jeffrey, Der Channing J, Hansen Steen H (July 2003). "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP". Curr. Biol. (England) 13 (13): 1106–15. doi:10.1016/S0960-9822(03)00418-4. ISSN 0960-9822. PMID 12842009. 
  8. ^ Katoh, Hironori; Harada Amane, Mori Kazutoshi, Negishi Manabu (May 2002). "Socius Is a Novel Rnd GTPase-Interacting Protein Involved in Disassembly of Actin Stress Fibers". Mol. Cell. Biol. (United States) 22 (9): 2952–64. doi:10.1128/MCB.22.9.2952-2964.2002. ISSN 0270-7306. PMC 133765. PMID 11940653. 

Further reading[edit]