Rnd2

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Rho family GTPase 2
Identifiers
Symbols RND2 ; ARHN; RHO7; RhoN
External IDs OMIM601555 MGI1338755 HomoloGene21123 GeneCards: RND2 Gene
RNA expression pattern
PBB GE RND2 213467 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8153 11858
Ensembl ENSG00000108830 ENSMUSG00000001313
UniProt P52198 Q9QYM5
RefSeq (mRNA) NM_005440 NM_009708
RefSeq (protein) NP_005431 NP_033838
Location (UCSC) Chr 17:
41.18 – 41.18 Mb
Chr 11:
101.46 – 101.47 Mb
PubMed search [1] [2]

Rnd2 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.[1] It is encoded by the gene RND2.[2]

It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM][2]

This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking.

The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1.[2]

Interactions[edit]

Rnd2 has been shown to interact with RACGAP1,[3] ARHGAP5[4] and UBXD5.[5]

References[edit]

  1. ^ Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. ISSN 0962-8924. PMID 16949823. 
  2. ^ a b c "Entrez Gene: RND2 Rho family GTPase 2". 
  3. ^ Naud, Nathalie; Touré Aminata; Liu Jianfeng; Pineau Charles; Morin Laurence; Dorseuil Olivier; Escalier Denise; Chardin Pierre; Gacon Gérard (May 2003). "Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells". Biochem. J. (England) 372 (Pt 1): 105–12. doi:10.1042/BJ20021652. ISSN 0264-6021. PMC 1223378. PMID 12590651. 
  4. ^ Wennerberg, Krister; Forget Marie-Annick; Ellerbroek Shawn M; Arthur William T; Burridge Keith; Settleman Jeffrey; Der Channing J; Hansen Steen H (Jul 2003). "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP". Curr. Biol. (England) 13 (13): 1106–15. doi:10.1016/S0960-9822(03)00418-4. ISSN 0960-9822. PMID 12842009. 
  5. ^ Katoh, Hironori; Harada Amane; Mori Kazutoshi; Negishi Manabu (May 2002). "Socius Is a Novel Rnd GTPase-Interacting Protein Involved in Disassembly of Actin Stress Fibers". Mol. Cell. Biol. (United States) 22 (9): 2952–64. doi:10.1128/MCB.22.9.2952-2964.2002. ISSN 0270-7306. PMC 133765. PMID 11940653. 

Further reading[edit]