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Rho family GTPase 2
Symbols RND2 ; ARHN; RHO7; RhoN
External IDs OMIM601555 MGI1338755 HomoloGene21123 GeneCards: RND2 Gene
RNA expression pattern
PBB GE RND2 213467 at tn.png
More reference expression data
Species Human Mouse
Entrez 8153 11858
Ensembl ENSG00000108830 ENSMUSG00000001313
UniProt P52198 Q9QYM5
RefSeq (mRNA) NM_005440 NM_009708
RefSeq (protein) NP_005431 NP_033838
Location (UCSC) Chr 17:
41.18 – 41.18 Mb
Chr 11:
101.46 – 101.47 Mb
PubMed search [1] [2]

Rnd2 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.[1] It is encoded by the gene RND2.[2]


It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM][2]

This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking.

Clinical significance[edit]

The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1.[2]


Rnd2 has been shown to interact with:


  1. ^ Ridley AJ (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. ISSN 0962-8924. PMID 16949823. 
  2. ^ a b c "Entrez Gene: RND2 Rho family GTPase 2". 
  3. ^ Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J et al. (Jul 2003). "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP". Curr. Biol. 13 (13): 1106–15. doi:10.1016/s0960-9822(03)00418-4. PMID 12842009. 
  4. ^ Naud N, Touré A, Liu J, Pineau C, Morin L, Dorseuil O et al. (May 2003). "Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells". Biochem. J. 372 (Pt 1): 105–12. doi:10.1042/BJ20021652. PMC 1223378. PMID 12590651. 
  5. ^ Katoh H, Harada A, Mori K, Negishi M (May 2002). "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers". Mol. Cell. Biol. 22 (9): 2952–64. doi:10.1128/mcb.22.9.2952-2964.2002. PMC 133765. PMID 11940653. 

Further reading[edit]